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https://www.selleckchem.com/products/gdc-0084.html The results in this report demonstrate that, although both single and repetitive blast exposures produce acute stress responses (weight loss, corticosterone increase), only repetitive blast exposure also results in co-occurring aversive/dysphoric-like stress responses. These results extend appreciation of the highly complex nature of repetitive blast exposure; and lend further support for the potential translational relevance of animal modeling approaches currently used by multiple laboratories aimed at elucidating the mechanisms (both molecular and behavioral) of repetitive blast exposure.Long-term, repeated exposure to low-intensity blast overpressure is a potential causal factor of lasting outcomes reminiscent of post-concussion syndrome. Wearable blast sensor engineers are exploring elements of blast that are associated with outcomes. Currently, however, there are no devices that can truly record all blasts experienced by an individual. Military service members (n = 984) were surveyed about their lifelong exposure and behavioral health. Using heavy-arms-associated target outcomes, we calculated a generalized blast exposure value (GBEV) for each participant. A threshold of 200,000 GBEV units was established at which a participant was likely to report more intense symptomology. If repetitive, low-intensity blast exposure has even a subtle effect over time, operational readiness could be negatively impacted. A threshold of exposure can inform decisions about how to reduce detrimental exposure. The GBEV can be used to track ongoing exposure and potentially identify those who may be at risk for developing blast-related outcomes.There is increasing empirical evidence that social distance and timing affect prosocial behavior after acute stress exposure. The present study focused on everyday moral decision-making after acute psychosocial stress and how it is influenced by effects of social closeness and timing. We expos

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