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https://www.selleckchem.com/products/pf-3644022.html , PPV and NPV for 12-lead ECG were 60.0%, 55.2%, 65.1%, 62.3% and 58.1%, respectively. Patients suffering from angina-like symptoms, with a logistic regression model value over 0.55, should be recommended for PCA. Patients suffering from angina-like symptoms, with a logistic regression model value over 0.55, should be recommended for PCA. Computed tomography (CT)-derived fractional flow reserve (FFR ) enables the non-invasive functional assessment of coronary artery stenosis. We evaluated the feasibility and potential clinical role of FFR in patients presenting to the emergency department with acute chest pain who underwent chest-pain CT (CPCT). For this retrospective IRB-approved study, we included 56 patients (median age 62 years, 14 females) with acute chest pain who underwent CPCT and who had at least a mild (≥25% diameter) coronary artery stenosis. CPCT was evaluated for the presence of acute plaque rupture and vulnerable plaque features. FFR measurements were performed using a machine learning-based software. We assessed the agreement between the results from FFR and patient outcome (including results from invasive catheter angiography and from any non-invasive cardiac imaging test, final clinical diagnosis and revascularization) for a follow-up of 3 months. FFR was technically feasible in 38/56 patients (68%). Eleven of tn who undergo CPCT provided that image quality is sufficient. FFRCT has the potential to improve patient triage by reducing further downstream testing but appears of limited value in patients with CT signs of acute plaque rupture. Propofol (PPF) overdose is a rare but lethal condition, which may lead to severe cardiac failure. In this study, we established an PPF-induced cardiac cytotoxicity model, and investigate the functional role of long non-coding RNA (lncRNA) small nucleolar RNA host gene 6 (SNHG6). Human induced pluripotent stem cell-derived cardiomyocytes (HiPSC-CMs) were exposed to

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