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https://www.selleckchem.com/products/17-AAG(Geldanamycin).html Extracellular vesicles (EVs) isolated from cardiosphere-derived cells (CDC-EVs) are coming to light as a unique cell-free therapeutic. Because of their novelty, however, there still exist prominent gaps in knowledge regarding their therapeutic potential. Herein the therapeutic potential of CDC-EVs in a rat model of acute traumatic coagulopathy induced by multiple injuries and hemorrhagic shock is outlined. Extracellular vesicle surface expression of procoagulant molecules (tissue factor and phosphatidylserine) was evaluated by flow cytometry. Extracellular vesicle thrombogenicity was tested using calibrated thrombogram, and clotting parameters were assessed using a flow-based adhesion model simulating blood flow over a collagen-expressing surface. The therapeutic efficacy of EVs was then determined in a rat model of acute traumatic coagulopathy induced by multiple injuries and hemorrhagic shock. Extracellular vesicles isolated from cardiosphere-derived cells are not functionally procoagulant and do not s. Although contrast-enhanced abdominal computed tomography (CEACT) is still considered the gold standard for the assessment of suspected acute diverticulitis, in recent years the use of point-of-care ultrasound (POCUS) has been spreading more and more in this setting. The aim of this study is to compare CEACT to POCUS for the diagnosis and staging of suspected acute diverticulitis. This is a prospective study conducted on 55 patients admitted to the Emergency Department of two Italian Hospitals with a clinical suspicion of acute diverticulitis between January 2014 and December 2017. All the patients included underwent POCUS first and CEACT immediately afterwards, with the diagnosis and the staging reported according to the Hinchey (H) classification modified by Wasvary et al. Three surgeons performed all the POCUS and the same two radiologists retrospectively analyzed all the CEACT images. The radiologist

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