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https://www.selleckchem.com/products/dubs-in-1.html Objective To identify risk factors associated with severe anaphylaxis in children STUDY DESIGN We carried out a multicenter prospective observational study including children less than 18 years old diagnosed with anaphylaxis in 7 Spanish pediatric emergency departments (ED) between May 2016 and April 2018. Children were considered to have severe anaphylaxis if they met one or more of the following criteria requirement for two or more doses of epinephrine, clinically important biphasic reaction, endotracheal intubation, intensive care unit admission, and/or death. Results We included 453 episodes of anaphylaxis. Of these, 61 were classified as severe anaphylaxis [13.5%, 95% CI (10.6-16.9)] 53 (11.7%) required more than one dose of epinephrine, and there were 14 (3.1%) cases of clinically important biphasic reactions, 2 (0.4%) intubations in the ED, and 6 (1.3%) admissions to the intensive care unit. No patients died. In the multivariable regression, we identified five independent risk factors for severe anaphylaxis history of asthma [p=0.002; OR 2.705, 95% CI (1.431-5.113)], onset of the symptoms less than 5 minutes after the allergen exposure [p=0.002; OR 2.619, 95% CI (1.410-4.866)], non-well appearance [P = .005; OR 2.973, 95% CI (1.380-6.405)], tachycardia [p=0.014; OR 2.339, 95% CI (1.191-4.959)] and hypotension [p=0.036; OR 3.725, 95% CI (1.087-12.762)] CONCLUSION Childhood anaphylaxis is usually well controlled in the ED. Children with a history of asthma, rapid onset of the symptoms, who are non-well appearing, or have tachycardia or hypotension upon arrival to the ED are more likely to have severe episodes.Objectives To compare patient reported outcomes in Blacks/African Americans with Whites participating in IBD Partners Kids & Teens, in order to identify possible racial health care disparities in pediatric inflammatory bowel disease (IBD) as future targets for improvement. Study design Cross-sectional ana

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