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https://www.selleckchem.com/products/r428.html The Swan Lagoon is a national nature reserve and an important spawning ground in China. In this study, we evaluated the concentration of heavy metals (Cd, Cr, Cu, Pb, and Zn) in different aquatic organisms (aquatic plants, crustaceans, mollusks, and fish), in order to examine their trophic transfer in food web. The results showed that the concentrations of Cd, Cu, Pb, and Zn were considerably higher in mollusks, whereas Cr concentrations were significantly higher in aquatic plants than in mollusks, crustaceans, and fish (p 0.05), indicating neither biomagnification or biodilution in the food web.Decabromodiphenyl ether (BDE-209) is a persistent environmental pollutant that poses great risks to human health and has been associated with glucose and lipid metabolism. However, the mechanisms by which BDE-209 disturbs glycolipid metabolism in the liver remain unclear. Therefore, this study sought to confirm the effects of BDE-209 on glycolipid metabolism in mice livers and L02 cells to elucidate potential mechanisms of action. In vivo BDE-209 exposure caused histological damage and lipid accumulation, elevated glucose, low-density lipoprotein, total cholesterol, and triglyceride levels, and decreased glycogen and high-density lipoprotein levels in mice livers. Moreover, in vitro BDE-209 exposure not only induced L02 cells cytotoxicity (i.e., reduced cell viability and increased LDH leakage and ROS generation) but also increased glucose and triglyceride concentrations in L02 cells. Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4. Moreover, GW9662, a PPARγ inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARγ/RXRα pathway in L02 cells induced by BDE

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