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https://www.selleckchem.com/products/SB-202190.html foliolosum. Ethnomedicinal studies revealed much wider scope of T. foliolosum in developing various drugs to solve multiple challenges in the health sector. Therapeutic effects were attributed to the bioactivities of the secondary metabolites present in T. foliolosum. CONCLUSIONS T. foliolosum is rich in berberine and other benzylisoquinoline alkaloids. T. foliolosum can be used as an excellent and effective herbal remedy for various human ailments since there are no reports on the toxicity of this herb. V.ETHNOPHARMACOLOGICAL RELEVANCE Anoectochilus Roxburghii (AR) has been used as a health food and a herb for the curative effect of longevity in China for hundreds years. AIM OF THE STUDY Pharmacological studies demonstrated that the plant ethanol extract possessed anti-oxidative and anti-aging effects on natural aging mice. However, it has not been reported whether the AR flavonoids extract (ARF) has a protective effect on oxidative stress in LO2 cells induced by H2O2 and D-gal induced aging mouse model. MATERIALS AND METHODS In this study, H2O2-induced oxidative stress LO2 cell model was performed to investigate the protective effect of ARF against H2O2 - induced oxidative damage in the LO2 cells by the method of MTT, the content of MDA and SOD, GSH-PX activities were determined. In D-gal induced aging mouse model, we observed behavioral assessment using the Morris water maze (MWM) and pathological morphology of the skin and liver, detected the biomarkers (SOD, GSH-PX, MDA, MAO, AChE) in serum, liver, brain and antioxidant-related gene expression in liver. RESULTS The data showed that ARF had certain protective effect on LO2 cells induced by H2O2 and effectively increased activities of SOD, GSH-PX, and decreased MDA content in cell supernatant. In vivo, ARF improved memory and the pathological morphology of skin and liver tissue, decreased MDA content, increased SOD, GSH-PX and MAO activity in varying degrees, an

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