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https://www.selleckchem.com/pharmacological_epigenetics.html The article provides a model of transformative leadership enabling leaders in business, government, science, education, culture, medicine, and other human activities to become Catalyzers of change and lead their institutions to-ward Strategic Harmony.Artificial Intelligence (AI) has been drawing attention in the field of medical devices. However, due to system complexity, the variability of their architecture, as well as ethical and regulatory concerns there is an ongoing need to analyze its application and performance.This study presents a narrative commentary on the applications of artificial neural networks (ANN) and machine learning (ML) algorithms in medical devices, past, current and future perspectives of application. One research focus of this study was on identifying problems and issues related to the implementation of AI in medical devices. The commentary is based on scientific articles published in PubMed, Scopus ad ScienceDirect databases, official publications of international organizations European Comission (EC), Food and Drug Administration (FDA), and World Health Organisation (WHO) published in 2009 - 2020 period. AI is revolutionizing healthcare, from medical applications to clinical engineering. However, before grasp-ing the full potential ethical, legal and social concerns need to be resolved and its application needs to be harmonized and regulated regarding equitable access, privacy, appropriate uses and users, liability and bias and inclusiveness.No significant therapeutic solutions for advanced cancer are available to date. However, an old idea based on usage of tumor-specific antibodies as the basis for a new vaccination form in patients with advanced tumors, has attracted recent research and is possible due to development of personalized neoantigenic vaccines. Each tumour has indeed, its own mutation content, only a small percentage are shared between patients. Technological advanc

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