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https://www.selleckchem.com/products/ly2157299.html 04). Astrocytes was greater in the non-active subjects in the midbrain (p=0.03) and basal ganglia (p=0.0004). MAP2 levels were higher for non-active participants in the basal ganglia (p=0.003) and similar between groups in the substantia nigra (p=0.46). Neurofilament levels for non-active participants were higher in the substantia nigra (p=0.006) but not in the basal ganglia (p=0.24). Active lifestyle seems to promote positive effects on brain by maintaining dopamine synthesis and structural protein expression in the nigrostriatal system and decrease astrogliosis in subjects with the same PD neuropathology burden. Active lifestyle seems to promote positive effects on brain by maintaining dopamine synthesis and structural protein expression in the nigrostriatal system and decrease astrogliosis in subjects with the same PD neuropathology burden.Many studies have found that non-pharmacological interventions, such as cognitive stimulation (CS), can benefit people with dementia (PWD) or with mild cognitive impairment (MCI). The use of the computerized cognitive stimulation (CCS) had proven to be an ally to those who want to detect and mitigate this disease. The purpose of this paper was to analyze the scientific production in CCS in PWD or with MCI in journals indexed in Clarivate Analytics' Web of Science and Elsevier's Scopus since 2000. Data collected from Web of Science and Scopus during 2000-2019. The data show that dementia research is exponentially developing following the evolution of widespread use of computer science. As such, this article was of enormous importance doing a bibliometric analysis of what has been done in the area since the beginning of this century. The search terms identified 61 papers related to the use of computers applied to CS in PWD or MCI, and the International Journal of Geriatric Psychiatry and Journal of Alzheimer's Disease had the largest number of publications. The most cited articl

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