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https://www.selleckchem.com/products/sr10221.html The structural integrity and functional stability of organelles are prerequisites for the viability and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases. In fact, those organelles synchronously present with evident structural derangement and aberrant function under exposure to different stimuli, which might accelerate the corruption of cells. Therefore, the quality control of multiple organelles is of great importance in maintaining the survival and function of cells and could be a potential therapeutic target for human diseases. Organelle-specific autophagy is one of the major subtypes of autophagy, selectively targeting different organelles for quality control. This type of autophagy includes mitophagy, pexophagy, reticulophagy (endoplasmic reticulum), ribophagy, lysophagy, and nucleophagy. These kinds of 2; SIAH1 siah E3 ubiquitin protein ligase 1; SNCA synuclein alpha; SNCAIP synuclein alpha interacting protein; SQSTM1/p62 sequestosome 1; STING1 stimulator of interferon response cGAMP interactor 1; TAX1BP1 Tax1 binding protein 1; TBK1 TANK binding kinase 1; TFEB transcription factor EB; TICAM1/TRIF toll-like receptor adaptor molecule 1; TIMM23 translocase of inner mitochondrial membrane 23; TNKS tankyrase; TOMM translocase of the outer mitochondrial membrane; TRIM tripartite motif containing; UCP2 uncoupling protein 2; ULK1 unc-51 like autophagy activating kinase; UPR unfolded protein response; USP10 ubiquitin specific peptidase 10; VCP/p97 valosin containing protein; VDAC voltage dependent anion channels; XIAP X-linked inhibitor of apoptosis; ZNHIT3 zinc finger HIT-type containing 3.CD19 chimeric antigen receptor T (CD19CAR-T) cell therapy has shown striking response in treating relapsed and refractory B-lineag

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