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https://www.selleckchem.com/products/fgf401.html To investigate the current evidence that correlates impaired male fertility with the risk of developing male-related malignancies. Systematic review and meta-analysis of population-based retrospective cohort studies. Not applicable. Men diagnosed with impaired fertility status and subsequently observed to determine incidence risk in developing testicular cancer (TCa) or prostate cancer (PCa). Not applicable. Pooled risk ratio (RR) differences among male factor infertility subjects compared with a fertile control population, and meta-regression analysis according to age at baseline, mean follow-up, range of study time, and year of publication. Six studies met the inclusion criteria and were critically examined. Four studies examined male infertility and TCa (n = 161,634; 174 TCa cases), and four examined infertility in relation to PCa (n = 183,950 men; 377 PCa cases) from 1963 to 2014. The pooled RR was 2.033 (95% confidence interval [CI], 1.66-2.48); heterogeneity Q = 3.04 (degree of freedom [df] = 3); I = 1.55% for TCa and 1.68 (95% CI, 1.17-2.4); Q = 23.3(df = 3); I = 87.1% for PCa. Male infertility was associated with a subsequent risk of both TCa and PCa. Although the clinical significance of these findings remains uncertain, future studies should evaluate the underlying mechanisms to determine whether testis and prostate screening practices should be altered in men with male infertility. PROSPERO 167277. PROSPERO 167277. To evaluate the association between invitro fertilization (IVF) and ischemic placental disease (IPD), stratified by gestational age. We performed a secondary analysis of a retrospective cohort study of deliveries. Deliveries were performed over 15 years at a single tertiary hospital. We included all parturients who had a live born infant or an intrauterine fetal demise (IUFD). We compared pregnancies resulting from IVF cycles to non-IVF pregnancies. The primary outcomes were preterm and term IPD

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