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https://www.selleckchem.com/products/ugt8-in-1.html 001; OR 1.14 [95% CI 1.09-1.21]) and GA at the time of fetal surgery (P .016; OR 1.37 [95% CI 1.07-1.77]) were independent predictors of postnatal ventriculoperitoneal shunting. CONCLUSION Fetuses with OSD who were operated on earlier in the gestational interval, which ranged from 19.7 to 26.9 weeks, were less prone to receiving postnatal ventriculoperitoneal shunts. © 2020 John Wiley & Sons, Ltd.Internal structure similarity in proteins can be observed at the domain and subdomain levels. From an evolutionary perspective, structurally similar elements may arise divergently by gene duplication and fusion events but may also be the product of convergent evolution under physicochemical constraints. The characterization of proteins that contain repeated structural elements has implications for many fields of protein science including protein domain evolution, structure classification, structure prediction, and protein engineering. FiRES (Find Repeated Elements in Structure) is an algorithm that relies on a topology-independent structure alignment method to identify repeating elements in protein structure. FiRES was tested against two hand curated databases of protein repeats MALIDUP, for very divergent duplicated domains; and RepeatsDB for short tandem repeats. The performance of FiRES was compared to that of lalign, RADAR, HHrepID, CE-symm, ReUPred, and Swelfe. FiRES was the method that most accurately detected proteins either with duplicated domains (accuracy = 0.86) or with multiple repeated units (accuracy = 0.92). FiRES is a new methodology for the discovery of proteins containing structurally similar elements. The FiRES web server is publicly available at http//fires.ifc.unam.mx. The scripts, results, and benchmarks from this study can be downloaded from https//github.com/Claualvarez/fires. © 2020 Wiley Periodicals, Inc.BACKGROUND We investigated the prognostic value of programmed death-ligand 1 (PD-L1) expressio

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