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https://www.selleckchem.com/products/icfsp1.html There were no differences in serum estradiol concentration (p=0.929) and duration of therapy (p=0.496) between formulations. Transgender women demonstrated hypercoagulable parameters on both thromboelastography (maximum amplitude +6.94mm (3.55, 10.33), p less then 0.001) and thrombin generation (endogenous thrombin potential +192.62nM.min (38.33, 326.91), p=0.009; peak thrombin +38.10nM (2.27, 73.94), p=0.034) but had increased overall fibrinolytic potential (+4.89% (0.52, 9.25), p=0.024) compared to cisgender men. No significant changes were observed relative to cisgender women. Route of estradiol delivery or duration of use did not influence the GCA parameters. Conclusion Transgender women on estradiol therapy demonstrated hypercoagulable GCA parameters compared to cisgender men with a shift towards cisgender female parameters. Route of estradiol delivery did not influence the GCA parameters.Affective vocalisations such as screams and laughs can convey strong emotional content without verbal information. Previous research using morphed vocalisations (e.g. 25% fear/75% anger) has revealed categorical perception of emotion in voices, showing sudden shifts at emotion category boundaries. However, it is currently unknown how further modulation of vocalisations beyond the veridical emotion (e.g. 125% fear) affects perception. Caricatured facial expressions produce emotions that are perceived as more intense and distinctive, with faster recognition relative to the original and anti-caricatured (e.g. 75% fear) emotions, but a similar effect using vocal caricatures has not been previously examined. Furthermore, caricatures can play a key role in assessing how distinctiveness is identified, in particular by evaluating accounts of emotion perception with reference to prototypes (distance from the central stimulus) and exemplars (density of the stimulus space). Stimuli consisted of four emotions (anger, disgust, fear, and plea

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