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https://www.selleckchem.com/products/gsk2606414.html INTRODUCTION The role of psychological factors in the manifestation and exacerbation of psoriasis are well known. Acute and chronic stress, anxiety and depression affect the reactions of innate and acquired immunity. The exacerbations of psoriatic lesions are accompanied by increased production of inflammatory mediators, which can contribute to the imbalance of neurotransmitters and the development of symptoms of depression and anxiety. THE AIM To assess the role of inhibitory neurotransmitters in the serum of patients with psoriasis exacerbation with comorbid emotional disorders. MATERIALS & METHODS 40 patients with psoriasis in the exacerbation stage were examined. Spielberger State-Trait Anxiety Inventory (STAI) and The Beck Depression Scale (BDI) were used to assess anxiety and depression parameters. We also evaluated the concentration of serotonin and gamma-aminobutyric acid (GABA) in the serum. RESULTS Patients with psoriasis had significant anxiety and depressive disorders. An imbalance in serotonin levels and decrease in serum GABA levels in patients with psoriasis in the acute stage were noted. Only patients with anxiety disorder had increased serotonin levels. CONCLUSIONS Our findings suggest that the imbalance of neurotransmitters in patients with psoriasis in the acute stage is important in predicting the development of the emotional wellbeing. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Climate change is increasingly impacting marine protected areas (MPAs) and MPA networks, yet adaptation strategies are rarely incorporated into MPA design and management plans according to the primary scientific literature. Here, we review the state of knowledge for adapting existing and future MPAs to climate change and synthesize case studies (n = 27) of how marine conservation planning can respond to shifting environmental conditions. First

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