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https://www.selleckchem.com/products/act001-dmamcl.html Extracellular vesicles (EVs) are cell secretory native components with long-circulation, good biocompatibility, and physiologic barriers cross ability. EVs derived from different donor cells inherit varying characteristics and functions from their original cells and are favorable to serve as vectors for diagnosing and treating various diseases. However, EVs nanotheranostics are still in their infancy because of their limited accumulation at lesion sites and compromised therapy efficiency. Hence, engineering modification of EVs is usually needed to further enhance their stability, biological activity, and lesion-targeting capacity. Herein, we overview the characteristics of EVs from different sources, as well as the latest developments of surface engineering and cargo loading methods. We also focus especially on advances in EVs-based disease theranostics. At the end of the review, we predict the obstacles and prospects of the future clinical application of EVs.Biological structures such as bone, nacre and exoskeletons are organized hierarchically, with the degree of isotropy correlating with the length-scale. In these structures, the basic components are nanofibers or nanoplatelets, which are strong and stiff but anisotropic, whereas at the macrolevel, isotropy is preferred because the direction and magnitude of loads is unpredictable. The structural features and mechanisms, which drive the transition from anisotropy to isotropy across length scales, raise fundamental questions and are therefore the subject of the current study. Focusing on the tibia (fixed finger) of the scorpion pincer, bending tests of cuticle samples confirm the macroscale isotropy of the strength, stiffness, and toughness. Imaging analysis of the cuticle reveals an intricate multilayer laminated structure, with varying chitin-protein fiber orientations, arranged in eight hierarchical levels. We show that the cuticle flexural stiffness is in

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