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Background and Aim The soft coral genus Sarcophyton is a source of cembraneterpen. Sarcophyton is reported to have anti-inflammatory properties, with the ability to reduce the expression of inducible nitric oxide synthase (iNOS) and inhibit nuclear factor-kappa B (NF-κB) activation. This study aimed to investigate the efficacy of dichloromethane (DCM) extracts of soft coral Sarcophyton spp. to inhibit the expression of NF-κB and iNOS induced by lipopolysaccharide (LPS). Materials and Methods Crude extracts of Sarcophyton spp. were macerated with DCM (13 v/v) for 24 h. Thirty-six Balb/c mice were divided into six treatment groups, namely, normal control (without LPS induction), negative control (LPS induction 4 mg/mL), comparative control (LPS+Dexamethasone 6 mg/kg), and 3 concentration groups extract (LPS+50, 125, and 250 mg/kg). The expression of NF-κB and iNOS was measured in each treatment group. Results Flow cytometry analysis showed that the relative number of NF-κB+ cells increased (18.38±1.24%) in LPS-induced mice compared with normal mice (13.24±1.15%). The Sarcophyton spp. https://www.selleckchem.com/products/gbd-9.html DCM extracts decreased the relative number of NF-κB+ cells (125 mg/kg 13.96±0.84%). Immunohistochemical analysis with ImmunoMembrane showed that LPS induction in mice increased iNOS expression when compared to normal mice. The Sarcophyton spp. DCM extracts reduced iNOS expression (especially at 125 mg/kg). Conclusion DCM extracts of Sarcophyton spp. inhibited the activation of NF-κB, resulting in suppressed iNOS expression, which directly inhibits NO production. Copyright © Riyadi, et al.Background and Aim Gastrointestinal infestations caused by intestinal parasites are the most important diseases and the most common in pigs in the tropics. These parasites are often associated with a huge economic loss. This study aimed to assess the diversity and prevalence of gastrointestinal parasites in farmed pigs from Haut-Ogooue Province, in South East Gabon. Materials and Methods From March 2018 to July 2018, 156 samples of pig feces collected from nine different farms were analyzed under light microscopy. The identification of eggs, cysts, and oocysts in fecal samples was done using two qualitative techniques Flotation and sedimentation. Results After examination, the results obtained revealed an overall infestation level of 98.7% (154/156). We found ten parasite types with infestation levels that varied from species Balantidium coli (120/156), Oesophagostomum spp. (100/156), Isospora suis (102/156), Ancylostoma spp. (17/156), Trichostrongylus spp. (28/156), Hyostrongylus spp. (13/156), Strongyloides spp. (7/156), Ascaris suum (8/156), Globocephalus spp. (1/156), and spirurida (1/156). The study of risk factors revealed that factors such as sex, age, and physiological condition may influence the diversity and level of infestation of animals by gastrointestinal parasites. Conclusion For better prevention of parasitism in these farms, it would be interesting to implement health monitoring and to ensure good hygiene. Finally, further studies would be needed to better evaluate the distribution of these parasites in Gabon and the involvement of these animals in the transmission cycle of parasitic zoonoses. Copyright © Maganga, et al.Perfluorochemicals (PFCs) are emerging contaminants in various water sources. Responsive polymers provide a new avenue for PFC adsorption/desorption from water. Poly-N-isopropylacrylamide's (PNIPAm's) temperature-responsive behavior and hydrophilic/hydrophobic transition is leveraged for reversible adsorption and desorption of PFCs. Adsorption of PFOA (perfluoro-octanoic acid) onto PNIPAm hydrogels yielded Freundlich distribution coefficients (Kd) of 0.073 L/g at 35 °C (above LCST) and 0.026 L/g at 22°C. Kinetic studies yielded second order rate constants (k2) of 0.012 g/mg/h for adsorption and 12.6 g/mg/h for desorption, with initial rates of 28 mg/g/h and 41 mg/g/h, respectively. Interaction parameters of PNIPAm's functional groups in its different conformational states, as well as the hydrophobic fluorinated carbon tails and hydrophilic head groups of PFOA are used to describe relative adsorption. Polyvinylidene difluoride (PVDF) provides a robust membrane structure for the commercial viability of polymeric adsorbents. Temperature swing adsorption of PFOA using PNIPAm functionalized PVDF membrane pores showed consistent adsorption and desorption capacity over 5 cycles. PFOA desorption percentage of 60% was obtained in pure water at temperatures below PNIPAm's lower critical solution temperature (LCST) while 13% desorption was obtained at temperatures above the LCST, thus showing the importance of the LCST on desorption performance.The majority of adults in the United States are overweight or obese, and yet Western ideals of beauty mean that low body fat composition is a component of physical attractiveness. In turn, perceived discrepancies between actual and ideal body shape and weight mean that many adults experience weight concerns-- and they also may be dissatisfied with their spouse's weight. This study examined whether weight concerns were linked to romantic relationship quality, an important domain of adult development. Specifically, we applied the Actor-Partner Interdependence Model to test how wives' and husbands' weight concerns and perceptions of their spouses' overweight contributed to their own and their spouse's reports of marital satisfaction and conflict over time. The sample was 197 heterosexual married couples (M age = 40.85 and 42.81 years for wives and husbands, respectively; M length of marriage = 18.6 years at Time 1) with children, who participated in a short-term longitudinal study of family relationships and adolescent development. Two-way interactions between partner perceptions of spouses' weight and gender indicated that husbands' perceptions that their wives were overweight predicted decreases in wives' marital satisfaction and increases in wives' reports of marital conflict across one year. In contrast, wives' perceptions of husbands' weight were not associated with changes in husbands' marital satisfaction or conflict. A two-way interaction between actor and partner weight concerns indicated that individuals reported more marital conflict when there was a discrepancy between their own and their spouse's weight concerns. Finally, a two-way interaction between actor and partner perceptions of spouse's weight indicated that, for individuals whose spouses rated them as below ideal weight, their perceptions of the spouse's overweight predicted their own lower marital satisfaction. Findings suggest that concerns about one's own and one's spouse's weight have negative ramifications for marital relationships.
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