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https://www.selleckchem.com/products/memantine-hydrochloride-namenda.html Purpose Oral lichen planus (OLP), is considered premalignant condition. This study tried to investigate the possibility of malignant transformation in OLP patients, by measuring the level of tumor suppressor protein p16INK4A, which is a product of the cyclin-dependent kinase inhibitor 2 (CDK2). CDK inhibitors may be responsible for maintenance of cell cycle. An imbalance in the cell cycle regulatory pathway involving p16/pRb may lead to unrestricted proliferation and tumorigenesis. Methods 40 patients with OLP underwent biopsy. Two control groups were included in this research, 13 healthy persons and 12 patients with oral squamous cell carcinoma (OSCC). All tissue samples were treated immunohistochemically using avidin-biotin peroxidase complex method. Results The number of patients with p16 positive cells was significantly higher in OLP (72.5%) in comparison to OSCC (33.33%). Although the prevalence of patients with p16 positive cells in OSCC was low, they expressed the highest percentage of p16 positive keratinocytes. Staining intensity of cytoplasm was also higher in p16 positive keratinocytes of OSCC in comparison to OLP. Conclusions These results suggest that inactivation of p16 is an early detectable event in oral tumorigenesis. P16 expression could also be connected with tumor grading and may be useful marker in oral tumor progression.Purpose The purpose of this bibliometric study was to point out the emergence and development of immunotherapy in cancer treatment and shifting tendencies on this field in the last years. We aimed to create an ease of access for the researchers of this dynamic field. Methods Cancer immunotherapy as a search term was queried into Thomson Reuter's Web of Science database of 2019 to list all the articles about this term. The top 100 cited articles were analyzed by topic, journal, author, year, institution, level of evidence, adjusted citation index and also t

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