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https://www.selleckchem.com/products/escin.html Together, these observations demonstrate a cooperative interplay between two RBPs, triggered differentially by the same stimulus, which exerts a synergistic effect on PDCD4 expression and thereby helps maintain a balance between inflammation and tumorigenesis.Promoting brain recovery after stroke is challenging as a plethora of inhibitory molecules are produced in the brain preventing it from full healing. Moreover, the full scope of inhibitory molecules produced is not well understood. Here, using a high-sensitivity UPLC-MS-based shotgun lipidomics strategy, we semi-quantitively measured the differential lipid contents in the mouse cerebral cortex recovering from a transient middle cerebral artery occlusion (MCAO). The lipidomic data were interrogated using the soft independent modeling of class analogy (SIMCA) method involving principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Statistics of the 578 confirmed lipids revealed 84 species were differentially changed during MCAO/reperfusion. The most dynamic changes in lipids occurred between 1 - 7 d post-MCAO, whereas concentrations had subsided to the Sham group level at 14 and 28 d post-MCAO. Quantitative analyses revealed a strong monotonic relationship between the reduction in PC(160/160) and the increase in LPC(160) levels (Spearman's Rs = -0.86) during the 1-7 d reperfusion period. Inhibition of cPLA2 prevented changes in the ratio between PC(160/160) and LPC(160), indicating altered Land's cycle of PC. A series of in vitro studies showed that LPC(160), but not PC(160/160), was detrimental to the integrity of neuronal growth cones and neuronal viability through evoking intracellular calcium influx. In contrast, PC(160/160) significantly suppressed microglial secretion of IL-1β and TNF-α, limiting neuroinflammation pathways. Together, these data support the role of the imbalanced ratio between PC(160/160) and LPC

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