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https://www.selleckchem.com/products/yo-01027.html Rapid-acting interventions for the suicide crisis have the potential to transform treatment. In addition, recent innovations in suicide research methods may similarly expand our understanding of the psychological and neurobiological correlates of suicidal thoughts and behaviors. This review discusses the limitations and challenges associated with current methods of suicide risk assessment and presents new techniques currently being developed to measure rapid changes in suicidal thoughts and behavior. These novel assessment strategies include ecological momentary assessment, digital phenotyping, cognitive and implicit bias metrics, and neuroimaging paradigms and analysis methodologies to identify neural circuits associated with suicide risk. This review is intended to both describe the current state of our ability to assess rapid changes in suicide risk as well as to explore future directions for clinical, neurobiological, and computational markers research in suicide-focused clinical trials.We report results of a cross-sectional survey conducted during March-April 2020 which marked the start and escalation of the COVID-19 crisis in Singapore. Our purpose was to examine whether reported feelings of gratitude among Chinese Singaporeans (N = 371; 124 males, 247 females; M age = 22.54, SDage = 3.63, age range 18-53 years) could be linked to adaptive responses to the pandemic. The results revealed that gratitude was associated with stronger endorsement of virus-prevention measures (β = 0.25, p = 0.001) that are necessary for protecting the physical health of oneself and others but disruptive to daily lives. Gratitude was also positively related to the tendency to perceive meaningful benefits in the crisis (β = 0.25, p = 0.002). Importantly, demonstrating the uniqueness and robustness of gratitude as a predictor of positive coping in response to the pandemic, these relationships remained significant when controlling for o

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