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https://www.selleckchem.com/products/arv-110.html Two recurrent (telomerase reverse transcriptase) promoter mutations, C228T and C250T, have been reported in thyroid carcinomas and were correlated with high-risk clinicopathological features and a worse prognosis. Although far more frequent in the poorly differentiated and undifferentiated thyroid cancer, the promoter mutations play a significant role on PTC recurrence and disease-specific mortality. However, the prevalence varies considerably through studies and it is uncertain if these differences are due to population variation or the methodology used to detect mutations. In this study we aim to compare three different strategies to detect promoter mutations in PTC. DNA was isolated from formalin-fixed paraffin-embedded (FFPE)specimens from 89 PTC and 40 paired lymph node metastases. The prevalence of the hot spot C228T and C250T mutations was assessed in FFPE samples using TaqMan SNP genotyping assays. Random samples were tested by Sanger Sequencing and droplet digital PCR (ddPCR). Innd individualized treatment decisions, mainly in highly heterogeneous tumors, require highly sensitive and specific approaches. This study observed a good concordance among the methodologies used to detect TERT promoter mutations when a high percentage of mutated alleles was present. Sanger analysis demonstrated a limit of detection for mutated alleles. Therefore, the prevalence of TERT promoter mutations in PTC may be higher than previously reported, since most studies have conventionally used Sanger sequencing. The efficient characterization of genetic alterations that are used as preoperative or postoperative diagnostic, risk stratification of the patient and individualized treatment decisions, mainly in highly heterogeneous tumors, require highly sensitive and specific approaches. Circulating albumin is negatively associated with adiposity but whether it is associated with increased energy intake, lower energy expenditure or weig
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