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https://www.selleckchem.com/products/ecc5004-azd5004.html MOG-IgG optic neuritis may present with relatively preserved visual function even at its nadir. Observation may be a reasonable strategy for these patients.We present a case with an atypical presentation of myelin oligodendrocyte glycoprotein associated disease (MOGAD) presenting with optic neuritis, short-segment transverse myelitis, and significant lymphocytic pleocytosis. The degree of lymphocytic pleocytosis in this case was unusually high and prompted extensive workup. Broad infectious and neoplastic work-up was unremarkable and raised the concern for aseptic meningitis. A literature review was performed of similar cases with documented CSF labs (see Table 1), which demonstrates the unique and significant pleocytosis noted in this case. There is no validation study evaluating 2015 International Panel for neuromyelitis optica (NMO) spectrum disorders (NMOSD) diagnosis (IPND) criteria in Chinese population. The association of myelin oligodendrocyte glycoprotein-immunoglobulin-G (MOG-IgG) with NMOSD was also not investigated in previous validation studies. Hence, we aimed to validate the 2015 NMOSD criteria in a cohort of Chinese patients, and to assess the association between MOG-IgG and NMOSD. We applied both the 2006 NMO and the 2015 NMOSD diagnostic criteria to all suspected NMOSD inpatients at the Department of Neurology of Chinese PLA general hospital diagnosed between 2016 and 2019. Demographics, core clinical features, AQP4-IgG and MOG-IgG status were retrieved and analyzed. A total of 185 patients fulfilling the 2015 NMOSD criteria (154 AQP4-IgG positive, 23 AQP4-IgG negative, 8 AQP4-IgG status unknown) were included, whereas only 43.2% (80/185) fulfilled the 2006 NMO criteria. After assuming all the NMOSD patients with unknown Aspace, that is, having isolated core clinical feature, was the main factor precluding NMOSD diagnosis under assumption of unknown AQP4-IgG status. NMOSD with MOG-IgG was no

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