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https://www.selleckchem.com/ Cellular distribution of biomolecules is important for regulating their function. In this issue of Developmental Cell, Chouaib et al., 2020 employ genetically tagged human cell lines to investigate the subcellular distribution of specific mRNAs and their encoded proteins, revealing several instances of localized translation with distinctive regulatory implications.How does auxin induce somatic embryogenesis? In this issue of Developmental Cell, Wang et al. uncover a regulatory role for auxin in the dynamics of chromatin accessibility and gene expression, which is critical for the establishment of developmental time-specific transcriptional regulatory networks orchestrating somatic-to-embryonic cell reprogramming and somatic embryo development.The ability to visualize transcription in real time in living organisms has enabled a new generation of gene expression studies in development. In this issue of Developmental Cell, Hoppe et al. show that the bone morphogenetic protein gradient is decoded through frequency modulation encoded by enhancers.Long non-coding RNAs (lncRNAs) are important regulators of development. In this issue of Developmental Cell, Wilson et al. utilize pluripotent stem cell models to demonstrate that a primate lncRNA, BANCR, is primarily expressed in fetal cardiomyocytes and promotes cell migration.Electron microscopy can resolve synapse ultrastructure with nanometer precision, but the capture of time-resolved, activity-dependent synaptic membrane-trafficking events has remained challenging, particularly in functionally distinct synapses in a tissue context. We present a method that combines optogenetic stimulation-coupled cryofixation ("flash-and-freeze") and electron microscopy to visualize membrane trafficking events and synapse-state-specific changes in presynaptic vesicle organization with high spatiotemporal resolution in synapses of cultured mouse brain tissue. With our experimental workflow, electrophysiological

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