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https://www.selleckchem.com/products/ly3009120.html The Positron emission tomography (PET) radioligand α-[11C]Methyl-L-tryptophan ([11C]AMT) has been used to assess tryptophan metabolism in cancer, epilepsy, migraine and autism. Despite the extensive application, the utility of this tracer is currently hampered by the short half-life of the radionuclide used for its labeling (11C, t1/2 = 20.4 min). We herein report the design, synthesis, radiolabeling and initial in vivo evaluation of a fluorine-18 (18F, t1/2 = 109.7 min) labeled analog that is fluorinated in the 6-position of the aromatic ring ([18F]6-F-AMTr). In a head-to-head comparison between [18F]6-F-AMTr and [11C]AMT in mice using PET, peak brain radioactivity, regional brain distribution and kinetic profiles were similar be-tween the two tracers. [18F]6-F-AMTr was however not a substrate for IDO1 nor TPH as determined in in vitro enzymatic assays. The brain uptake of the tracer is thus more likely related to LAT1 transport over the blood-brain barrier than metabolism along the serotonin or kynurenine pathways.Graphene-based strain sensors have attracted tremendous interest due to their potential application as intelligent wearable sensing devices. However, for graphene-based strain sensors, it is found that the sensing property at the beginning of the tensile cycle is not stable. Concretely, the peak resistance value gradually declines in the first dozens of cycles in every cyclic test. This is a problem that obviously affects the measurement accuracy but is rarely investigated so far. In this paper, this phenomenon is for the first time systematically studied. According to the reliable experimental results, it can be concluded that the decline of resistance is caused by the evolution of wrinkle morphologies in the graphene layer, which is essentially attributed to the temporary slippage of the graphene sheets under external stress. Based on the analyzed mechanism, a targeted improvement solution was propose

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