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https://www.selleckchem.com/products/MDV3100.html 2.2 times, compared to group 2 and 3, respectively. An analysis of MMP-1 and MMP-2 concentration in patients of groups 1 and 2 revealed a significant (p=0.04) decrease in their activity in severe POP (III-IV). In women of the group 2, biopsy of the vaginal wall showed that expression of vimentin and smooth muscle actin in the connective tissue was significantly higher, than in group 1 and 3 (p less then 0.05). Vimentin expression in the group 2 was 1.4 and 2.6 times higher than in the group 1 and 3, respectively. In the control group, the expression of these markers in the vaginal wall was minimal and focal. CONCLUSION Our data indicate that fibrosis and degradation of the connective tissue in the vaginal wall predominate in POP, and these changes are a consequence, but not a cause of PG. The aggravation of degenerative changes in the connective tissue leads to the progression of POP.AIM To evaluate the efficiency of combined transrectal ozone and magnetic therapy for the treatment of chronic bacterial prostatitis (CBP). MATERIALS AND METHODS A total of 142 men with CBP were included in the study and allocated to different treatment, including standard therapy for 6 weeks (n=40), transrectal magnetic therapy in addition to standard therapy (n=35), transrectal ozone therapy in addition to standard therapy (n=37), transrectal magnetic and ozone therapy in addition to standard therapy (n=30). Treatment results were evaluated 3 months after the completion of therapy. RESULTS The most pronounced positive improvement in all evaluated parameters was observed among patients who received both magnetic and ozone therapy, according to the criteria of all domains of the NIH-CPSI questionnaire, IIEF-5 questionnaire, and based on the changes in prostate volume, maximum urination rate, residual urine volume and microscopic examination of prostate secretion. CONCLUSION To achieve optimal results in the treatment of CBP, it is necess

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