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https://www.selleckchem.com/GSK-3.html 5%, and 71.5% after 12, and 50.0%, 52.7% and 75.7% after 24months; p = < 0.001) and to allow an interval extension to ≥ 12weeks (28.6%, 34.2%, and 53.3% after 12, and 34.2%, 47.7%, and 41.7% after 24months; p = < 0.001). The portion of eyes achieving disease stability regressed in the second year, whereas the portion of eyes under a ≥ 12-week interval increased. This discrepancy may reflect the challenges in balancing between under-treatment and a reduced treatment burden. The portion of eyes achieving disease stability regressed in the second year, whereas the portion of eyes under a ≥ 12-week interval increased. This discrepancy may reflect the challenges in balancing between under-treatment and a reduced treatment burden. To report the anatomical characteristics of wide-based foveal pit and its possible associations with macular diseases. Wide-based foveal pit was defined as a foveal base width (FBW) larger than the mean value plus one standard deviation of the normal population. Eyes with a wide-based foveal pit were retrospectively collected as the study group, and age- and sex-matched subjects with a normal FBW were recruited as the control group. FBW, area of foveal avascular zone (FAZ), and retinal artery trajectory (RAT) were compared between the two groups. The characteristics of the fellow eyes in the study group were also described. Fifty-two eyes from 52 patients were identified as having a wide-based foveal pit; 43 (82.7%) were female. Both their FBW (474.7 ± 84.6 μm) and area of FAZ (0.50 ± 0.11 mm ) were significantly larger than in the control group (297.6 ± 42.3 μm and 0.29 ± 0.10 mm , respectively; p < 0.001 for both), and they also had a wider RAT than the control group (p < 0.001). During follow-up, three eyes had developed idiopathic epiretinal membrane. As for their fellow eyes, they either also had a wide-based foveal pit (11 eyes) or had various macular diseases including idiopathic epiretinal membrane

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