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https://www.selleckchem.com/products/ro5126766-ch5126766.html CDC reference classified more children as attaining low or normal weight, against WHO or IOTF (p≤0.001 for all). Lowest prevalence of ideal and excess weight was recorded by CDC, compared to all other standards (p≤0.001 for all). All BMI z-scores provided moderate associations with FEV1%. CONCLUSION Large variations across weight status classification were present when employing three growth standards in school-aged CF patients. Given than BMI z-scores from all references provided comparable associations with pulmonary function, our data indicate that no studied reference is better than others in assessing growth in CF.BACKGROUND AND OBJECTIVE Acute Severe Colitis (ASC) is a potentially life-threatening event. Optimal timing for second-line treatment in children is mainly based on the clinical score PUCAI. The aim of our study was to evaluate the potential role of bowel ultrasound scan (BUS) in predicting the need of second-line therapy in ASC. METHODS Patients aged 3.4 mm) and loss of CWS as independent predictors of steroid-resistance. CONCLUSIONS BUS is a non-invasive, easily accessible and cost-effective resource that may identify at an early stage first-line therapy failure in pediatric ASC.OBJECTIVE Menopausal vasomotor symptoms (VMS) may result from altered thermoregulatory control in brain regions innervated by neurokinin 3 receptor-expressing neurons. This phase 2b study evaluated seven dosing regimens of fezolinetant, a selective neurokinin 3 receptor antagonist, as a nonhormone approach for the treatment of VMS. METHODS Menopausal women aged >40-65 years with moderate/severe VMS (≥50 episodes/wk) were randomized (double-blind) to fezolinetant 15, 30, 60, 90 mg BID or 30, 60, 120 mg QD, or placebo for 12 weeks. Primary outcomes were reduction in moderate/severe VMS frequency and severity ([number of moderate VMS × 2] + [number of severe VMS × 3]/total daily moderate/severe VMS) at weeks 4 and 12

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