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https://www.selleckchem.com/products/zx703.html 757)]. "Higher number of children" [OR = 0.714, CI (0.519, 0.981)] and higher "income satisfaction" [OR = 0.771, CI (0.619, 0.959)] were independent protective factors against severe burnout. The burnout rate in ICU physicians in China is high. Difficult treatment decisions, the number of children, and income satisfaction are independently associated with burnout rates among ICU physicians in China. Burnout syndrome of the Chinese personnel working in intensive care units a survey in China, ChiCTR-EOC-17013044, registered October 19, 2017. http//www.chictr.org.cn/showproj.aspx?proj=22329 . Burnout syndrome of the Chinese personnel working in intensive care units a survey in China, ChiCTR-EOC-17013044, registered October 19, 2017. http//www.chictr.org.cn/showproj.aspx?proj=22329 . Delirium is defined as acute organic brain dysfunction characterised by inattention and disturbance of cognition. It is common in the intensive care unit and is associated with poorer outcomes. Good quality sleep is important in the prevention and management of delirium. Melatonin is a natural hormone secreted by the pineal gland which helps in the regulation of the sleep-wake cycle. It is possible that melatonin supplementation in intensive care improves sleep and prevents delirium. The 'Prophylactic Melatonin for Delirium in Intensive Care' study is a multi-centre, randomised, double-blinded, placebo-controlled trial. The primary objective of this study is to determine whether melatonin given prophylactically decreases delirium in critically ill patients. A total of 850 ICU patients have been randomised (11) to receive either melatonin or a placebo. Participants were monitored twice daily for symptoms of delirium. This paper and the attached additional files describe the statistical analysis plan (SAP) for the trial. The SAP has been developed and submitted for publication before the database has been locked and before the treatment allocati

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