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https://www.selleckchem.com/products/tacrine-hcl.html Bonding of carbon fiber reinforced polymer (CFRP) plates to a concrete member is a widely used strengthening method. CFRP plates used in construction degrade due to harsh environmental conditions such as high temperature or alkaline solution seepage from concrete. However, the adhesive between CFRP plates and concrete may have a positive effect on the durability performance of CFRP plates. In this paper, the long-term performance of both naked and adhesive coated CFRP pultruded plates subjected to different-temperature water or alkaline solution (20, 40 and 60 °C) are investigated to evaluate the protective effect of adhesive on CFRP plates. It is found that the adhesive coating can slow the deterioration of mechanical properties especially the tensile properties and fiber-matrix interfacial properties. The water absorption mechanism of CFRP plates was also investigated.Immune-suppression driven Hepatitis B Virus (HBV)-reactivation poses serious concerns since it occurs in several clinical settings and can result in severe forms of hepatitis. Previous studies showed that HBV strains, circulating in patients with HBV-reactivation, are characterized by an enrichment of immune-escape mutations in HBV surface antigen (HBsAg). Here, we focused on specific immune-escape mutations associated with the acquisition of N-linked glycosylation sites in HBsAg (NLGSs). In particular, we investigated profiles of NLGSs in 47 patients with immunosuppression-driven HBV-reactivation and we evaluated their impact on HBsAg-antigenicity and HBV-replication in vitro. At HBV-reactivation, despite a median serum HBV-DNA of 6.7 [5.3-8.0] logIU/mL, 23.4% of patients remained HBsAg-negative. HBsAg-negativity at HBV-reactivation correlated with the presence of >1 additional NLGSs (p less then 0.001). These NLGSs are located in the major hydrophilic region of HBsAg (known to be the target of antibodies) and resulted from the single mutation T1

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