https://www.selleckchem.com/products/cpi-0610.html The model also effectively reproduced the dose, dose rate and oxygen tension dependence of responses to FLASH radiotherapy in a range of systems, with model parameters compatible with published data. CONCLUSIONS Oxygen depletion provides a credible quantitative model to understand the biological effects of FLASH radiotherapy and is compatible with a range of experimental observations of FLASH sparing. These results highlight the need for more detailed quantification of oxygen depletion under high dose rate radiation exposures in relevant systems, and the importance of oxygen tension in target tissues for FLASH sparing to be observed. BACKGROUND Approximately 8% of children have food allergy. Yet, little is known about how parents cope with the burden of this disease. OBJECTIVE To describe the perceptions of food allergy-related mental health issues of parents of children with food allergy. METHODS Parents of children with pediatric allergist-diagnosed food allergy were recruited via allergy clinics and education centres in a large, Canadian city. We used content analysis to identify overarching themes. RESULTS We interviewed 21 parents with children (boys (13/21; 62.9%) age less then 12 months-16 years. Interviews averaged 47 (range 33-82) minutes. Most children were diagnosed as infants, and few (7/21; 33.3%) were monoallergic. About one-half (7/16; 43.8%) had a history of anaphylaxis. For parents of children with a single food allergy, " Accommodation and Adaptation " was described. In contrast, parents with multiple food allergic children described " Anxiety and Isolation ," and spoke of being "depressed" and "terrified" about leaving their children in the care of others who may not be equipped to handle food allergy. Many parents felt "overwhelmed and alone," especially if they lacked support from extended family and/or their social circle. " Fear for today, fear for the futur e" was commonly described by parent