https://www.selleckchem.com/products/sivelestat-sodium.html 7, similar to the value obtained for the control drug tirapazamine (tirapazamine (TPZ), SI = 4). Although the compounds showed distinct cytotoxic activities, the electrochemical behaviors of HL1-HL3 were very similar, as were the behaviors of complexes (1-3). Complex (2) deserves special interest since it was significantly more active under hypoxia than under normoxia conditions. Hence, in this case, selective reduction of the nitro group in a low oxygen pressure environment, resulting in toxic reactive oxygen species (ROS) and damage to DNA or other biomolecules, might operate, while for the remaining compounds, other modes of action probably occur. Copyright © 2020 American Chemical Society.A material design approach was taken for the preparation of an organic ionic plastic crystal (OIPC)-polymer electrolyte material that exhibited both good mechanical and transport properties. Previous attempts to form this type of electrolyte material resulted in the solvation of the OIPC by the ionomer and loss of the plastic crystal component. Here, we prepared, in situ, a macrophase-separated OIPC-polymer electrolyte system by adding lithium bis(fluorosulfonyl)imide (LiFSI) to a (PAMPS-N1222) ionomer. It was found that an optimal compositional window of 40-50 mol % LiFSI exists whereby the electrolyte conductivity suddenly increased 4 orders of magnitude while exhibiting elastic and flexible mechanical properties. The phase behavior and transport properties were studied using differential scanning calorimetry and 7Li and 19F solid-state nuclear magnetic resonance spectroscopy. This is the first example of a fabrication principle that lends itself to a wide range of promising OIPC and ionomeric materials. Subsequent studies are required to characterize and understand the morphology and conductive nature of these systems and their application as electrolyte materials. Copyright © 2020 American Chemical Society.A series