in English, German Wir berichten über den ungewöhnlichen Krankheitsverlauf von drei Patienten mit gastro-intestinalen MALT-Lymphomen. Besonderheiten sind die primäre Manifestation der Lymphome, die hochmaligne Transformation im weiteren Verlauf, der lange Zeitraum zwischen initial erfolgreicher kurativ intendierter Therapie und dem Rezidiv und das Auftreten einer weiteren Neoplasie in einem Fall. Dies zeigt, dass trotz der allgemein guten Prognose von gastrointestinalen MALT-Lymphomen Nachsorgeuntersuchungen sinnvoll sind.in English, German Das Bouveret-Syndrom ist eine seltene Komplikation des Gallensteinleidens. Es werden sowohl chirurgische als auch endoskopische Interventionen durchgeführt, wobei die Krankheit streng interdisziplinär zu sehen ist. Etablierte Empfehlungen zum Vorgehen existieren nicht. In diesem Beitrag wollen wir über unsere Erfahrungen aus 6 Fällen in 3 Schweizer Spitälern von 2015 bis 2017 berichten. Wir beschreiben ein endoskopisches Vorgehen, das die elektrohydraulische Lithotripsie mit einer anschliessenden Ballondilatation kombiniert, und schlagen einen Behandlungsalgorithmus vor.in English, German PURPOSE  The aim of this study was to investigate the potential of multiparametric 18F-FDG PET/MR imaging as a platform for radiomics analysis and machine learning algorithms based on primary cervical cancers to predict N- and M-stage in patients. MATERIALS AND METHODS  A total of 30 patients with histopathological confirmation of primary and untreated cervical cancer were prospectively enrolled for a multiparametric 18F-FDG PET/MR examination, comprising a dedicated protocol for imaging of the female pelvis. The primary tumor in the uterine cervix was manually segmented on post-contrast T1-weighted images. Quantitative features were extracted from the segmented tumors using the Radiomic Image Processing Toolbox for the R software environment for statistical computing and graphics. 45 different image features were calculated from non-enhanced as well as post-contrast T1-weighted TSE images, T2-weighted TSE images, the ADC map, the parametric Ktrans, Kep, Ve and iAUC maps and PET images, resdiction of the metastatic status of cervical cancers. · Prediction of M-stage is superior to N-stage. · Multiparametric PET/MRI displays a valuable platform for radiomics analyses .We aimed to characterize cardiac-autonomic responses to a 13-day preseason camp in the heat among an American college football team. Players were categorized as linemen (n=10) and non-linemen (n=18). RHR, natural logarithm of the root-mean square of successive differences multiplied by twenty (LnRMSSD), and subjective wellbeing (LnWellness) were acquired daily. Effect sizes±90% confidence interval showed that for linemen, LnRMSSD decreased (moderate) on day 2 (71.2±10.4) and increased (moderate) on day 12 (87.1±11.2) relative to day 1 (77.9±11.2) while RHR decreased (small-moderate) on days 6, 7, and 12 (67.7±9.3-70.4±5.5 b∙min-1) relative to day 1 (77.1±10.1 b∙min-1). For non-linemen, LnRMSSD increased (small-large) on days 3-5, 7, 12, and 13 (83.4±6.8-87.6±8.5) relative to day 1 (80.0±6.5) while RHR decreased (small-large) on days 3-9, 12, and 13 (62.1±5.2-67.9±8.1 b∙min-1) relative to day 1 (70.8±6.2 b∙min-1). Decrements in LnWellness were observed on days 4-10 and 13 for linemen (moderate) and on days 6-9, 12, and 13 for non-linemen (small-moderate). Despite reductions in LnWellness, cardiac-autonomic parameters demonstrated responses consistent with heat-acclimation, which possibly attenuated fatigue-related decrements. © Georg Thieme Verlag KG Stuttgart · New York.Acute prolonged endurance running has been shown to alter muscle-specific circulating microRNA (miRNA) levels. Here, eighteen participants completed an 8 km run. We assessed the levels of hsa-miR-1-3p, -133a-3p, -133b, and -206 and their correlation with conventional biomarkers following exercise. Compared to before exercise (Pre), 8 km run significantly increased the lactate level immediately after exercise (0 h). Myoglobin (Mb) level increased at 0 h while creatine kinase (CK) level increased 24 h after exercise (24 h). The levels of creatine kinase MB isoenzyme (CK-MB) and cardiac troponin I (cTnI) were all elevated at 24 h and within the normal physiological range; The levels of hsa-miR-1-3p, -133a-3p, -133b significantly increased at 0 h but only hsa-miR-133a-3p still elevated at 24 h. Only hsa-miR-206 level decreased at 24 h; Additionally, the changes of hsa-miR-1-3p and hsa-miR-133a-3p were correlated with Mb at 24 h. These findings suggest that muscle-specific miRNA elevation in plasma is likely physiological and that these miRNA may be used as potential biomarkers for load monitoring in individuals. © Georg Thieme Verlag KG Stuttgart · New York.Over recent decades the association between metabolic and gas exchange parameters during exercise has become evident. Different "thresholds" (such as lactate thresholds, critical power, EMG thresholds) and intensity domains appear to be linked to an upper limit of oxygen uptake steady state (V̇O2SS). The aim of this study was to investigate whether MLSS is associated with the upper limit for a V̇O2SS.  https://www.selleckchem.com/products/necrostatin-1.html  Forty-five subjects underwent one incremental test and 4-6 30-minute MLSS tests on a cycle ergometer. A three-component model was used to describe V̇O2 response at PMLSS and just above PMLSS+1. To evaluate the results, breath-by-breath V̇O2 and lactate (LA) values were analyzed using the intraclass correlation coefficient (ICC), increasing (k-) values and the Wilcoxon test. According to the calculated k-values of LA and VO2 at PMLSS and PMLSS+1, no significant increase of VO2 occurred during both intensities (PMLSS and PMLSS+1) from minute 10 to minute 30, confirming the existence of a V̇O2SS. Additionally, the ICC of 0.94 confirmed high accordance of the VO2 kinetics at both intensities (PMLSS and PMLSS+1). This study shows that power output at MLSS workload does not represent an accurate cut for an upper limit of V̇O2SS. © Georg Thieme Verlag KG Stuttgart · New York.The phase angle is used to evaluate nutritional status and is an indicator of cellular health. Cardiorespiratory fitness and body composition are strong indicators of health during adolescence. We aimed to evaluate if body composition and cardiorespiratory fitness have an association with phase angle among adolescents. 203 girls and 220 boys (12.8±1.3 years) were evaluated. Peak height velocity, percentage fat mass, fat-free mass, cardiorespiratory fitness, and phase angle measurements were collected. Linear regression adjusted by peak height velocity was used to verify if predictor variables were associated with phase angle among adolescents. Phase angle showed correlation with fat-free mass (girls r=0.42 and boys r=0.37); with percent fat mass (girls r=0.23); and with cardiorespiratory fitness (boys r=0.19). Linear regression showed that percentage fat mass (in girls) and cardiorespiratory fitness (in boys) had an effect of 11 and 17% in phase angle, respectively, while fat-free mass had an effect of 22 and 26% in phase angle for girls and boys, respectively.