BACKGROUND Limited information is available on the application of diode laser in the treatment of peri-implant diseases. The aim of this study was to investigate the clinical efficacy of the adjunctive application of diode laser in the non-surgical treatment of peri- implant mucositis during a 12-month follow-up period. METHODS The sample was composed of 73 systemically healthy patients with one implant diagnosed with peri-implant mucositis (bleeding on probing [BoP] with no loss of supporting bone). Implants were randomly assigned to mechanical debridement with hand and powered instruments and 980-nm diode laser application (test group, N= 38) or mechanical debridement alone (control group, N= 35). At the completion of active treatment patients were included in a periodontal maintenance program. Recalls were provided every three months in both treatment groups for reinforcement in oral hygiene instructions and professional implant cleaning with rubber cups. Baseline parameters were repeated at 3 and 12 months postoperatively. RESULTS Intragroup analysis showed that plaque index, BoP and probing depth presented statistically significant improvements when compared with baseline values (all P less then 0.001). No statistically significant difference in clinical outcomes was observed between treatment groups at each time point. At 12 months no significant difference in the percentage of sites showing BoP resolution was observed between test (60.9%) and control treatment (52.6%), as well. CONCLUSIONS Based on the present results, the adjunct use of diode laser showed little but not statistically significant additional benefits in the treatment of peri-implant mucositis after an observation period of one year.BACKGROUND The aim of the present study was to compare bulk-filled composite resins with conventional composites in terms of cuspal movement and micro-leakage scores. METHODS Ninety-six maxillary premolar teeth with mesial-occclusal-distal cavities were allocated to four groups. Twelve teeth in each group was treated etch rinse, self-etch or selective-etch (n=8) protocols with respective adhesive system. Bucco-palatal cusp measurements were performed before and after preparation, and 180s after curing and then subjected to 5000 thermocyclws. After immersed in 0.2% basic fuchsin dye for 24h, cervical micro-leakage was evaluated. The data was analyzed by One-way ANOVA and post-hoc Tukey's honest Test (p=0.05). RESULTS All groups and bonding protocols revealed no significant differences in total cuspal deflection measurement and micro-leakage scores. After preparation, a significant increase was found in bucco-palatal width of the teeth compared to baseline (p=0.002). There were no significant relationship among composite resins and adhesives (p>0.05). CONCLUSIONS Cuspal relief after cavity preparation should be taken into account when evaluation deflection.We read with enthusiasm the recent article by Tang et al. entitled "Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia," which is a retrospective analysis of the coagulation profile of 183 patients admitted with pneumonia secondary to the 2019-nCoV (COVID-19).1 This article deals with a timely topic and brings up important points that need to be interrogated in future studies. This article is protected by copyright. All rights reserved.BACKGROUND Trends of paediatric emergency visits (ED) for dental conditions have been broadly discussed; however, little has been published in the Canadian context. AIM To describe the utilization of ED for dental conditions among children and to investigate demographic characteristics influencing its use. DESIGN A comprehensive review of records of all children aged 1 to 17 years who attended the ED service of a paediatric hospital in Montreal, Canada for dental conditions over a ten-year period (2004-2013) was completed. Information on the child's principal dental diagnosis, sociodemographic data and source of referral were obtained. RESULTS A total of 10,905 paediatric ED visits were seen during the study period. Among the children, 54.7% were male and the majority was younger than 6 years old. Dental caries constituted the most common reason for ED presentation comprising close to 43% of total visits for a dental complaint. Females, teenagers and self-referred children were more likely to experience ED visits due to non-traumatic dental conditions. CONCLUSIONS The utilization of ED for dental conditions has increased among preschool children in the last decade and was mostly due to caries-related dental problems. Effective preventive strategies are needed to improve the oral health condition of children. This article is protected by copyright.  https://www.selleckchem.com/GSK-3.html  All rights reserved.Pneumocystis jirovecii pneumonia (PCP) is caused by a ubiquitous, opportunistic fungus that can lead to substantial morbidity and mortality in immunocompromised individuals, including solid organ transplant (SOT) recipients. Many studies evaluating interventions to prevent PCP have been conducted primarily in populations that were immunocompromised due to conditions other than organ transplantation; when evaluated in SOT recipients, most were adults. This article is protected by copyright. All rights reserved.BACKGROUND Endothelium-derived prostacyclin and nitric oxide elevate platelet cyclic nucleotide levels and maintain quiescence. We previously demonstrated a synergistic relationship exists between cyclic nucleotides and P2Y12 receptor inhibition. A number of clinically approved drug classes can modulate cyclic nucleotide tone in platelets including activators of NO-sensitive guanylyl cyclase (GC) and phosphodiesterase (PDE) inhibitors. However, the doses required to inhibit platelets produce numerous side effects including headache. OBJECTIVE We investigated using GC-activators in combination with P2Y12 receptor antagonists as a way to selectively amplify the anti-thrombotic effect of both drugs. METHODS In vitro light transmission aggregation and platelet adhesion under flow were performed on washed platelets and platelet rich plasma. Aggregation in whole blood and a ferric chloride-induced arterial thrombosis model were also performed. RESULTS The GC-activator BAY-70 potentiated the action of the P2Y12 receptor inhibitor prasugrel active metabolite in aggregation and adhesion studies and was associated with raised intra-platelet cyclic nucleotide levels.