https://www.selleckchem.com/products/arv-110.html e AVC outperforms radiologist readers.Chondrosarcoma is a malignant cartilage matrix-producing tumour. Those arising de novo are called primary chondrosarcomas and are the second commonest primary malignant bone tumours. Numerous types of primary chondrosarcoma exist, namely conventional central (intramedullary), periosteal (juxta-cortical), clear cell, mesenchymal, and dedifferentiated. The biologic aggressiveness, prognosis and thus management of chondrosarcoma are dependent on the histological sub-type and grade. Accurate pre-operative diagnosis is therefore essential in determining management and outcome which requires a multidisciplinary approach taking into account clinical features, imaging findings and histopathology. In this review, we present the pertinent multimodality imaging features which aid in the differentiation of low-grade and high-grade conventional central chondrosarcoma. To investigate the utility of post-acquisition computed diffusion-weighted imaging (cDWI) for primary prostate cancer (PCa) evaluation in biparametric whole-body MRI (bpWB-MRI). Patients who underwent pelvic MRI for PCa screening and subsequent bpWB-MRI for staging were included. Two radiologists assessed the diagnostic performance of the following datasets for clinically significant PCa diagnosis (grade group ≥2 according to the Prostate Imaging-Reporting and Data System, version 2.1) bpMRI (axial DWI scans with a b-value of 2,000 s/mm + axial T2WI scans from pre-biopsy pelvic MRI), computed bpWB-MRI (computed WB-DWI scans with a b-value of 2,000 s/mm + axial WB-T2WI scans), and native bpWB-MRI (native axial WB-DWI scans with a b-value of 1,000 s/mm + axial WB-T2WI scans). Systemic biopsy was used as reference standard. Fifty-one patients with PCa were included. The areas under the curve (AUCs) of bpMRI (0.89 for reader 1 and 0.86 for reader 2) and computed bpWB-MRI (0.86 for reader 1 and 0.83 for reader 2) were significantly h