Studying generalisation of associative learning requires analysis of response gradients measured over a continuous stimulus dimension. In human studies, there is often a high degree of individual variation in the gradients, making it difficult to draw conclusions about group-level trends with traditional statistical methods. Here, we demonstrate a novel method of analysing generalisation gradients based on hierarchical Bayesian curve-fitting. This method involves fitting an augmented (asymmetrical) Gaussian function to individual gradients and estimating its parameters in a hierarchical Bayesian framework. We show how the posteriors can be used to characterise group differences in generalisation and how classic generalisation phenomena such as peak shift and area shift can be measured and inferred. Estimation of descriptive parameters can provide a detailed and informative way of analysing human generalisation gradients.
  To determine the efficacy of paracetamol and tramadol analgesia via patient controlled pump and intermittent administration using the Short-Form McGill Pain Questionnaire after L4/L5 discectomy in neurosurgical patients.
 
  Fourteen months prospective quantitative study with 200 neurosurgical patients' participation who underwent elective discectomy of the L4/L5 intervertebral disc extrusion. The study was conducted due to a patient-controlled analgesia pump and intermittent analgesia application. Pain was assessed using the Short-Form McGill Pain Questionnaire in the Croatian language during the zero, first, and second postoperative day.
 
  Perception of pain was reduced in patient controlled analgesia pump groups after the second measurement during the first postoperative day [95% CI -3.89, -0.76], regardless of administered analgesic (
  <0.001). After the final measurement, at 7 PM on the second postoperative day, the differences were not significant (
  =0.070). This study results are registered and allocated in the Australian New Zealand Clinical Trials Registry (ANZCTR).
 
  Analgesia administration via patient-controlled pump contributes to the alleviation of postoperative pain after L4/L5 disc extrusion surgery regardless of administered analgesic.
 Analgesia administration via patient-controlled pump contributes to the alleviation of postoperative pain after L4/L5 disc extrusion surgery regardless of administered analgesic.
  Because of low acceptance rates and limited capacity, complete diagnostic autopsies (CDAs) are seldom conducted in low- and middle-income countries (LMICs). There have been growing investments in less-invasive postmortem examination methodologies, including needle-based autopsy, known as minimally invasive autopsy or minimally invasive tissue sampling (MITS). MITS has been shown to be a feasible and informative alternative to CDA for cause of death investigation and mortality surveillance purposes.
 
  The aim of this narrative review is to describe historical use and evolution of needle-based postmortem procedures as a tool to ascertain the cause of death, especially in LMICs.
 
  Key word searches were conducted in PubMed and EBSCO in 2018 and 2019. Abstracts were reviewed against inclusion and exclusion criteria. Full publications were reviewed for those abstracts meeting inclusion criteria and a start set was established. A snowball search methodology was used and references for all publications meeting incmination.
 Although there is evidence of less-invasive postmortem sampling starting in the 1800s, more structured needle-based postmortem examination publications started to appear in the mid-twentieth century. Early studies were mostly conducted in high-income countries but starting in 2010 the number of publications began to increase, and a growing number of studies were conducted in LMICs. Initial studies in LMICs were disease-specific but since 2015 have evolved to include more expansive postmortem examination.The Alderney Race, located northwest of the Cotentin Peninsula (France), is a site with high tidal-stream energy potential. Circulation through the Alderney Race is complex, with current speed exceeding 3 m s-1 at neap tide. Towed acoustic Doppler current profiler (ADCP) measurements and static point velocity measurements were performed in July 2018 focusing on assessment of circulation and vertical structure of tidal currents. Transect surveys revealed peculiar features of local dynamics such as change in location of the tidal jet on ebb and flood flow. The spatial expanse of the tidal jet was quantified and regions with largely sheared or nearly homogeneous velocity distributions were identified on the cross-sections. Velocity profiles acquired along the cross-sections were accurately characterized using a power law. The spatial variability of the power-law exponent α was found to be large and correlated with the tidal conditions. The largest variation in profile shape was observed in the northern sector and assumed to be generated by the current interaction with a bathymetric constriction. The velocity profiles were found to vary from highly sheared on flood flow to nearly homogeneous on ebb flow, with corresponding range of power-law exponent α variation from 6 to 14. In the southern sector, over a relatively smooth bathymetry, the velocity profile shape was accurately approximated using the 1/7 power law with a range of variation of α from 6.5 to 8, with respect to the tidal conditions. To our knowledge, this is the largest field survey done using towed ADCP and the results could represent a significant advance in tidal site characterization and provide advanced information to turbine developers. This article is part of the theme issue 'New insights on tidal dynamics and tidal energy harvesting in the Alderney Race'.This study presents an overview of the main hydrodynamic features of the Alderney Race strait based on in situ measurements and two-dimensional hydrodynamic model simulations. The strait encompasses a large amplitude of tidal properties (tidal range and tidal wave propagation) and particularly strong currents exceeding 5 m s-1 with associated counter currents and gyres. Variations in depth, sea bottom roughness, coastal topography and current orientation around the La Hague Cape provide access to a large variety of original hydrodynamic regimes. Some are revealed as locations with a 0.4 m drop in the mean sea level associated with strong average currents.  https://www.selleckchem.com/pharmacological_epigenetics.html  A resonance effect associated with the offshore currents can also be observed close to the coasts. The 'St Martin whistle' occurs in a bay whose gyre centre oscillates with a reversal of the measured current every 5-7 min. The Alderney Race represents a particular area of interest for coastal hydrodynamic studies. The available in situ measurement datasets are rich with recordings of sea levels; acoustic Doppler current profiler current profiles; surface radar currents; waves; dye experiments; surface and in-depth dissolved tracer surveys.