https://www.selleckchem.com/products/nsc16168.html STUDY DESIGN Retrospective review of prospectively collected database. OBJECTIVE To delineate and visualize trajectories of the functional status in surgically-treated adult spinal deformity (ASD) patients. SUMMARY OF BACKGROUND DATA Classifying long-term recovery following ASD surgery is not well defined. METHODS 1,171 surgically-treated patients with a minimum of 3-year follow-up were included. The group-based trajectory modeling (GBTM) was used to identify distinct trajectories of functional status over time, measured by Oswestry Disability Index (ODI). Patient profiles were then compared according to the observed functional patterns. RESULTS The GBTM identified four distinct functional patterns. The first group (10.0%) started with minimal disability (ODI 15 ± 10) and ended up almost disability-free (low-low). The fourth group (21.5%) began with high ODI (66 ± 11) and improvement was minimal (high-high). Groups two (40.1%) and three (28.4%) had moderate disability (ODI 39 ± 11 versus 49 ± 11, p  less thenately disabled patients with good mental health. GBTM permits classification into distinct groups, which can help in surgical decision making and setting expectations regarding recovery. LEVEL OF EVIDENCE 3.OBJECTIVE Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. METHODS We searched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used "menopause," "hot flushes," "vasomotor symptoms," "gabapentin," and "non-hormonal therapy." Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and dropout rate. We estimated the standardized mean difference (S