Our observations need to be verified in large-scale studies to determine if these terms are meaningful for nursing practice in that they describe something not expressed with 'dyspnea'. There is the possibility of confusion due to the use of inappropriate terms and a lack of education on the subject. Many nurses used these terms, and there may be things that the term 'dyspnea' could not express. The results of this study can be used to identify something that is lacking in communication about dyspnea between nurses, nurses and patients, and nurses and patients' families. Asian/Pacific Island Nursing Journal, Volume 4(4) 144–150, ©Author(s) 2020, https//kahualike.manoa.hawaii.edu/apin/.Studies on women have identified breastfeeding confidence as an important variable in influencing breastfeeding outcomes. The mother's breastfeeding self-efficacy in the early postpartum period was a strong predictor of the duration of breastfeeding. This study aims to assess the breastfeeding self-efficacy of the postpartum mothers in urban barangays of San Jose Occidental Mindoro. The respondents of the study were 200 early postpartum mothers distributed equally chosen from four purposively selected urban barangays. The data collection technique was through a survey interview using 14-item Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) and a demographic questionnaire. Descriptive and inferential statistics were used to analyze the data. The study revealed that postpartum mothers responded in the study were confident and has self-efficacy in breastfeeding their child as measured through technique and intrapersonal thought in breastfeeding. Moreover, the number of prenatal check up was positively correlated with breastfeeding self-efficacy. The result of the study can be used as a baseline assessment tool in the hospital at delivery to assist in identifying women who are at risk for early weaning. Asian/Pacific Island Nursing Journal, Volume 4(4) 135–143, ©Author(s) 2020, https//kahualike.manoa.hawaii.edu/apin/.Parents had better to assess their infant's skin daily to prevent the development of any skin problems. However, there are no standard methods for assessing infant skin at home. This study aimed to validate the assessment of infant face skin conditions by parents as compared to using skin barrier function clinical tests. In addition, we evaluated the degree of agreement between parents and physicians/midwives when assessing an infant's skin. A cross-sectional study involving 184 infants aged 3 months was conducted. To evaluate the parents' infant skin assessment, we used the Neonatal Skin Condition Score (NSCS). On the same day, we evaluated the skin barrier function on the infant's forehead and cheek, including transepidermal water loss (TEWL), stratum corneum hydration, skin pH, and sebum secretion. Skin barrier function values were correlated with infant skin condition assessed by parents, especially in cases of TEWL of the cheek, for which a moderate positive correlation was found between parental assessment score (ρ = 0.448). In addition, infant with skin problems based on parental assessment had a significantly higher TEWL, lower SCH, and higher skin pH. However, there was weak agreement between parental and physician/midwife assessment. Thus, there was a relationship between parental assessment and skin barrier function; thus, parents can use at-home assessment to assist with infant skin care. In the future, research focused on developing methods of examining infant skin conditions should consider incorporate parental daily skin assessment. Asian/Pacific Island Nursing Journal, Volume 4(4) 159–164, ©Author(s) 2020, https//kahualike.manoa.hawaii.edu/apin/.Oncolytic viruses are promising immunoreagents. Numerous studies have shown that oncolytic virotherapy is effective for many tumors. Herein, we investigated the therapeutic effect of oHSV2, an oncolytic type 2 herpes simplex virus, on mouse colon carcinoma. The in vivo antitumor efficacy of oHSV2 was observed in both unilateral and bilateral colon cancer models. oHSV2 effectively eliminated tumors and prolonged the survival of mice without side effects. Additionally, treatment with oHSV2 effectively prevented the growth of rechallenged tumors and distant implanted tumors. The specific killing ability of splenic immune cells to tumor cells was enhanced. oHSV2 treatment effectively reduced the content of inhibitory immune cells (regulatory T cells [Tregs] and myeloid-derived suppressor cells [MDSCs]) and increased the content of positive immune cells (natural killer [NK], CD8+ T, and dendritic cells [DCs]) in the spleen. Moreover, treatment with oHSV2 remodeled the tumor immune microenvironment. In summary, treatment with oHSV2 can effectively eliminate primary tumors, generate tumor-specific immunity, and elicit immune memory to inhibit tumor recurrence and metastasis. Furthermore, this virotherapy can reshape the immune status of the spleen and tumor microenvironment in mice, which can further improve the therapeutic antitumor effect. © 2020 The Authors.Functional elimination of p53 is a common feature of a large percentage of human malignancies. Here, we report the development of a pharmacological strategy aimed at restoring p53 function and its use for targeted therapy in p53-deficient mice. Specific inhibition of deubiquitinases ubiquitin-specific peptidase 14 (USP14) resulted in durable tumor regressions of autochthonous lymphomas and sarcomas in p53-deficient mice without affecting normal tissues, and therapeutic response was correlated with an increase in the ubiquitination of constitutive photomorphogenesis 9 (COP9) signalosome subunit 5 (COPS5), a key negative regulatory effector for p53.  https://www.selleckchem.com/products/protosappanin-b.html  Inhibition of USP14 resulted in durable tumor regression through COPS5 deubiquitilation and a p53-dependent and -independent regulation mechanism by USP14. This series highlights the utility of proteasome deubiquitinating activity inhibition as a novel treatment paradigm for p53-deficient cancers. In addition, it provides preliminary evidence that inhibition of USP14 resulted in durable tumor regression through COPS5 deubiquitilation and p53-dependent and -independent regulation mechanism by USP14. These findings suggest that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target for patients with p53 deficiency. © 2020 The Authors.