BACKGROUND Using Newcastle 85+ Study data, we investigated transitions between frailty states from age 85 to 90 years and whether multi-morbidities and socioeconomic status (SES) modify transitions. METHODS The Newcastle 85+ Study is a prospective, longitudinal cohort study of all people born in 1921 in Newcastle and North Tyneside. Data included a multidimensional health assessment; general practice record review (GPRR) and date of death. Using the Fried phenotype (participants defined as robust, pre-frail or frail), frailty was measured at baseline, 18, 36 and 60 months. RESULTS Frailty scores were available for 82% (696/845) of participants at baseline. The prevalence of frailty was higher in women (29.7%, 123/414) than men (17.7%, 50/282) at baseline and all subsequent time points. Of those robust at baseline, 44.6% (50/112) remained robust at 18 months and 28% (14/50) at age 90. Most (52%) remained in the same state across consecutive interviews; only 6% of the transitions were recovery (from pre-frail to robust or frail to pre-frail), and none were from frail to robust. Four or more diseases inferred a greater likelihood of progression from robust to pre-frail even after adjustment for SES. SES did not influence the likelihood of moving from one frailty state to another. CONCLUSIONS Almost half the time between age 85 and 90, on average, was spent in a pre-frail state; multi-morbidity increased the chance of progression from robust and to frail; greater clinical intervention at the onset of a first chronic illness, to prevent transition to multi-morbidity, should be encouraged. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society.BACKGROUND delirium is an acute state of confusion that affects >20% of hospitalised patients. Recent literature indicates that more severe delirium may lead to worse patient outcomes and health system outcomes, such as increased mortality, cognitive impairment and length of stay (LOS). METHODS using systematic review methodology, we summarised associations between delirium severity and patient or health system outcomes in hospitalised adults. We searched MEDLINE, EMBASE, PsycINFO, CINAHL and Scopus databases with no restrictions, from inception to 25 October 2018. We included original observational research conducted in hospitalised adults that reported on associations between delirium severity and patient or health system outcomes. Quality of included articles was assessed using the Newcastle-Ottawa Scale. The level of evidence was quantified based on the consistency of findings and quality of studies reporting on each outcome. RESULTS we included 20 articles evaluating associations that reported mortality (n = 11), cognitive ability (n = 3), functional ability (n = 3), patient distress (n = 1), quality of life (n = 1), hospital LOS (n = 4), intensive care unit (ICU) LOS (n = 2) and discharge home (n = 2). There was strong-level evidence that delirium severity was associated with increased ICU LOS and a lower proportion of patients discharged home. There was inconclusive evidence for associations between delirium severity and mortality, hospital LOS, functional ability, cognitive ability, patient distress and quality of life. CONCLUSION delirium severity is associated with increased ICU LOS and a lower proportion of patients discharged home. Delirium severity may be a useful adjunct to existing delirium screening to determine the burden to health care system resources. © The Author(s) 2020.  https://www.selleckchem.com/products/hdm201.html  Published by Oxford University Press on behalf of the British Geriatrics Society.This article reports a copper doped boehmite (CBH) based nano-material which is capable of detecting and removing hexavalent chromium simultaneously. Basic characterization has been performed to determine its phase purity, particle size (∼20 nm), morphology and surface properties (surface area 15.29 m2 g-1 and pore diameter 3.9 nm) by using some basic characterization tools. The Rietveld refinement method has been adopted to analyze the microstructural details of the synthesized nanostructure. Photoinduced electron transfer (PET) based quenching of fluorescence is mainly responsible for chromium sensing in this case. This nanosensor is exceptionally sensitive (limit of detection ∼ 6.24 μM) and merely selective towards hexavalent chromium ions. Industrial wastewater samples have also been used here to demonstrate the real life applicability of this material, which shows the same trend. This fluoro-sensor gains its multi-functionality when it comes to the adsorption based removal of Cr(vi) from wastewater. The synthesized material shows a remarkably high adsorption rate (∼85% in just 5 minutes) due to its sponge-like porous structure. Adsorption of hexavalent chromium from wastewater enhances the dielectric constant of this material significantly (∼7.93 times). Ionic polarization-dependent enhancement of the dielectric constant resulting from industrial wastewater treatment is a quite unmarked approach. Very low tangent loss with augmented dielectric permittivity makes this nano-material desirable for energy harvesting applications. Previously many articles have reported the sensing and removal of various industrial effluents. Keeping this in mind, this work has been designed and, apart from sensing and removal, it provides a new insight into energy harvesting from wastewater.We investigate the photogenerated electron kinetics of a thermal-decomposed polymeric carbon nitride (TCN) synthesized in air using femtosecond time-resolved diffuse reflectance spectroscopy. We find that the oxygen functional groups in TCN contribute to the formation of reactive shallow trap states for photogenerated electrons, leading to an enhanced activity for photocatalytic hydrogen evolution.Herein, we show two new DNA binding small molecules, NCD-RO and NCD-RC, and their ability to bind and selectively assemble ruthenium complexes on G-G mismatch DNA. This study used a naphthyridine carbamate dimer (NCD) as an efficient scaffold to assemble metal complexes in a controlled manner on dsDNA.