https://www.selleckchem.com/products/mln-4924.html Muscle synergy is a fundamental mechanism of motor control. Despite a number of studies focusing on muscle synergy during power grip and pinch at high-level force, relatively less is known about the functional interactions between muscles within low-level force production during precision pinch. Traditional analytical tools such as nonnegative matrix factorization or principal component analysis have limitations in processing nonlinear dynamic electromyographic signals and have confined sensitivity particularly for the low-level force production. In this study, we developed a novel method - multiplex muscle networks, to investigate the dynamical coordination of muscle activities at low-level force production during precision pinch. The multiplex muscle network was constructed based on multiplex limited penetrable horizontal visibility graph (MLPHVG). Seven forearm and hand muscles, including brachioradialis (BR), flexor carpi ulnaris (FCU), flexor carpi radialis (FCR), flexor digitorum superficialis (FDS), exe classification accuracy of 82.21%. These findings reveal related alterations of functional interactions between muscles involved in precision pinch. The novel method for constructing multiplex muscle network may provide insights into muscle synergies during precision pinch force control.Assistive devices, including canes or crutches, are used in partial weight-bearing (PWB) to offload weight from limbs weakened by disease or injury, promote recovery, and prevent reinjury. While weight must be offloaded accurately to target loads prescribed by healthcare providers for maximum benefit, current training methods result in poor adherence. It is, however, currently unknown how best to provide feedback during training so that users can build an accurate internal model for PWB. In this work, we investigate seven feedback schemes using an instrumented cane, which vary the modality, timing, and the level of detail provi