https://www.selleckchem.com/products/ly-3475070.html for multifocal pancreatic tumors sparing the proximal pancreatic body. This operation can achieve acceptable functional outcomes but large series with long-term follow up are needed to evaluate the advantages and results of MSP. Heat shock protein (HSP)-90 promotes tumor growth and is overexpressed in many malignancies. HSP90 expression profile and its potential as a therapeutic target in primary and metastatic neuroendocrine tumors (NETs) are not known. HSP90 cytoplasmic expression and Ki-67 index were re-reviewed and scored by a pathologist blinded to all other clinicopathologic variables for patients who underwent resection of primary and metastatic gastroenteropancreatic (GEP) neuroendocrine tumors at a single institution (2000-2013). Primary outcome was recurrence-free survival (RFS). Of 263 tumors reviewed, 73% (n=191) were primary GEP NETs, and 12% (n=31) were NET liver metastases. Of the primary GEP-NETs, mean age was 56 years, 42% were male; 53% (n=103) were pancreatic and 23% (n=44) were small bowel. HSP90 expression was high in 34% (n=64) and low in 66% (n=127). Compared to low expression, high HSP90 was associated with advanced T-stage (T3/T4) (47 vs 27%; p=0.02). #link# Among patients who underwent curative-intent resecti pathologic factors. HSP90 inhibition may be a potential therapeutic target for neuroendocrine tumors.Individuals with Autism Spectrum Disorder (ASD) have high rates of "comorbidity". Research on concurrent substance use (disorder) in ASD, however, is scarce and findings have been inconsistent. This study aims at assessing the prevalence of risk drinking in adolescent and young adult twins with and without autism spectrum problems. Data from a Swedish longitudinal nationwide twin study were analyzed. Across three age groups of 15- (N = 10,050), 18- (N = 7,931) and 24-year-olds (N = 2,882) prevalence rates of risk drinking were compared between twins with and without an ASD proxy diagn