Amennyiben az SN-ben nem igazolódott ECT, de ABD történt, akkor a pN1-érintettség aránya 82%-os, míg a pN2+pN3 aránya 18%-os volt. Az ECT-pozitív ABD-s csoportban a pN1-érintettség 60%-os volt, míg a pN2+pN3 arány 40%-osnak bizonyult, amely az ECT-negatív csoport kétszerese; ez a különbség szignifikáns (p = 0,038). Következtetések Az ECT a hónalj masszív nyirokcsomó-érintettség prediktora, ezért ha ECT igazolódik, akkor ez egy olyan tényező, amelyet az ABD-ről való döntésben figyelembe kell venni.Objective To review the efficacy and safety of niraparib for the treatment of recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer (OC, FTC, and PPC). Data Sources A literature search via MEDLINE through PubMed from August 2013 to January 2020 was performed using the key terms niraparib, PARP inhibitors, ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. Study Selection and Data Extraction Completed and ongoing trials were identified through a review of the website trial registry https//www.clinicaltrials.gov . Data Synthesis In a phase III, double-blind clinical trial, progression-free survival improved in patients treated with niraparib compared with placebo as maintenance treatment for patients with platinum-sensitive, recurrent OC 21 versus 5.5 months in the germline breast cancer susceptibility gene (gBRCA) cohort (hazard ratio [HR] = 0.27; 95% CI = 0.17 to 0.41; P less then 0.001) and 9.3 versus 3.9 months in the overall nongermline breast cancer susceptibility gene (non-gBRCA) cohort (HR = 0.45; 95% CI = 0.34 to 0.61; P less then 0.001). Adverse events included thrombocytopenia and anemia. Relevance to Patient Care and Clinical Practice Poly (ADP-ribose) polymerase (PARP) inhibitors have gained a place in the therapeutic management of OC, FTC, and PPC because of their ability to suppress growth of homologous recombination deficiency-positive tumors, including those with BRCA1/2 mutations. Niraparib inhibits the DNA repair mechanism vital to the survival of cancer cells, poly-ADP ribose polymerase. Conclusions PARP inhibitors can be used as a single agent for maintenance therapy for platinum-sensitive recurrent disease in patients with partial or complete response following 2 or more rounds of platinum-based therapy.The kinetics of the reaction of OH radicals with hydroxyacetone has been investigated as a function of temperature at a total pressure of helium of 2.0-2.1 Torr and over an extended temperature range of T = 250-830 K and as a function of pressure at T = 301 K in the pressure range 1.0-10.4 Torr. The rate constant of the reaction OH + CH3C(O)CH2OH → products (1) was measured using both absolute (from the kinetics of OH consumption in excess of hydroxyacetone) and relative rate methods (k1 = 4.7 × 10-22 × T3.25 exp (1410/T) cm3 molecule-1 s-1 at T = 250-830 K).  https://www.selleckchem.com/products/abc294640.html  The present data combined with selected previous temperature-dependent studies of reaction (1) yield k1 = 4.4 × 10-20 × T2.63 exp (1110/T) cm3 molecule-1 s-1, which is recommended from the present work at T = 230-830 K (with conservative uncertainty of 20% at all temperatures). k1 was found to be independent of the pressure in the range from 1.0 to 10.4 Torr of He at T = 301 K. The present results are compared with previous experimental and theoretical data.The role of gold nanoparticles (AuNPs) in the degradation of tyrosine intermediates formed during the radiation induced ●OH reaction with tyrosine at pH 6.5 is investigated by measuring the radiolytic yields, G, of tyrosine (-Tyr), dityrosine and 3, 4 dihydroxyphenylalanine. The G(DT) is doubled, while G(-Tyr) calculated is halved in the presence of 6.0 × 10-10 mol dm-3 AuNPs. Pulse radiolysis studies iscarried out to elucidate the mechanism and nature of the transient formed in the reaction of ●OH and ●N3 with tyrosine. The formation of tyrosyl radical in the presence of AuNPs is found to be a major pathway through the decay of tyrosine-●OH adducts via water elimination reaction which is found to be 3x faster in the presence of AuNPs. Quantum chemical calculations on the system showed favorable formation of tyrosine-AuNPs complex. A new plausible mechanism of tyrosine-AuNPs complex acting as Lewis type catalyst in the decay of tyrosine-●OH adducts leading to reduced DOPA formation is proposed. The proposed mechanism are also complemented by the electronic spectra and energetics of the reaction of ●OH with tyrosine using Density Functional Theory (DFT) calculations. Significantly, H-shift reaction of ortho-tyrosine-●OH adducts is also found to be energetically viable. The investigation provides a new physical insight of the effect of AuNPs on the decay of free radical transient species and demonstrates the potential of radiation chemical techniques and quantum chemical calculations as a tool for understanding the impact of metal nanoparticles in free radical oxidation of amino acids which is important in the use of metal nanoparticles for biomedical applications.An easy, effective, and reversible strategy for tuning the Krafft temperature (KT) of selenium-containing ionic surfactants, with head groups ranging in nature from anionic to amphoteric, has been achieved for the first time via the redox chemistry of selenium. After oxidation with H2O2, the selenide group was converted to a more hydrophilic selenoxide group. This made the oxidized forms of the surfactants more water-soluble, which results in a marked reduction in the KT. In contrast, the hydrophilic selenoxide was restored to its reduced form of selenide via reduction reaction, which allowed the KT value to return to its initial value. By alternating the oxidization and reduction treatments, the KT of the selenium-containing surfactants in this work could be reversibly switched over 5-10 cycles without causing obvious adverse distortions.We have probed a series of multicomponent electron donor2-donor1-acceptor1 conjugates, both experimentally and computationally. The conjugates are based on the light harvester and primary electron-donor zinc-porphyrin (ZnP, donor1), to whose β-positions a secondary electron-donor ferrocene (Fc, donor2) and the primary electron-acceptor C60-fullerene (C60, acceptor1) are linked via p-phenylene-acetylene bridges of different lengths. This modular approach makes full control over shuttling electrons and holes between C60, ZnP, and Fc possible. Different charge-separation, charge-transfer, and charge-recombination routes have been demonstrated, both by transient absorption spectroscopy measurements on the femto, pico-, nano-, and microsecond time scales and by multi-wavelength and target analyses. The molecular wire-like nature of the p-phenylene-acetylene bridges as a function of C60-ZnP and ZnP-Fc distances is decisive in the context of generating distant and long-lived C60•‒ ZnP Fc•+ charge-separated states. For the first time, we confirm the presence of two adjacent charge-transfer states, a C60 ZnP•‒ Fc•+ intermediate in addition to C60•‒ ZnP•+ Fc, en route to the distant C60•‒ ZnP Fc•+ charge-separated state.