It is recommended that practitioners working with junior AF players to consider developing a force-orientated sprint acceleration profile to improve sprinting performance.
  Effective teaching and learning mathematics is important to achieve good results during an academic and professional career. This is especially difficult for visually impaired students because of difficulties in managing structural information included in maths formulae.
 
  The extended multimedia alternative method, including the problem of decomposition and knowledge vector, were presented and compared to the classical teaching method. A qualitative method to evaluate motivation during the process of teaching and learning maths for impaired students, which includes eleven detailed motivators, has been developed.
 
  The alternative teaching method offers statistically significant improvements in four of the eleven proposed assessment categories success in progress - adjusting the difficulties of learning, presentation of the material, approval group/individual and alternative presentation of mathematic materials. The experiments carried out allowed the authors to increase the knowledge about the limitations eriments and research results, it can be concluded that applying the proposed method of decomposition together with evaluation procedure based on the vector of knowledge in the process of teaching and learning of mathematics by visually impaired may increase their motivation positively. Implications for Rehabilitation The key aspects of the alternative method of presenting math formulae are included in the bellow points • It increases the availability of materials containing structured information (mathematical formulae) for the blind. • It limits the importance of communication barriers in math education the possibility of self-study, reducing costs - by reducing the number of individual tutorials. • It contributes to the development of universal rules for the structural presentation of information • It increases the independence of the student from the teacher.
  To investigate the effect of cosmetic camouflage in health-related quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and permanent facial skin damage.
 
  This is a randomized controlled clinical trial (Universal Trial Number U1111-1210-2554e) with SLE women from outpatients using ACR/1997 and/or SLICC/2012 criteria, aged over 18 years old, with modified SLEDAI 2k < 4 and permanent facial skin damage, recruited in two tertiary centers to use cosmetic camouflage (n = 36) or no intervention (n = 20). Endpoints were score variations in SLE Quality of Life (SLEQoL) (total and each domain), Dermatology Life Quality Index (DLQI), Rosenberg self-esteem scale and Hospital Anxiety and Depression Scale (HADS), after daily use of cosmetic camouflage for 12 +/-2 weeks (Phase I), "as needed" use of cosmetic camouflage for another 12 +/-2 weeks (Phase II), and during total follow up (24 +/-2 weeks).  https://www.selleckchem.com/products/piperaquine-phosphate.html  Univariate and multivariate linear regressions were conducted by protocol analysis.
 
  Both groups wnent facial skin damage.
 The use of cosmetic camouflage improved the HRQoL in female SLE patients with permanent facial skin damage.
  Peripheral neurologic manifestations may be associated with most of the collagen vascular diseases including systemic lupus erythematosus (SLE), yet most of the times it is not clear what therapy should be prescribed. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations suggest the use of glucocorticoids and immunosuppressive agents for the treatment of SLE associated peripheral neuropathy (PN) (strength of statement A, category of evidence 1), however these recommendations are based on studies that did not focus specifically on PN but rather on neuropsychiatric manifestations of SLE out of which only one was a randomized controlled clinical trial that included 7 patients with peripheral neuropathy. The objective of this systematic review is to determine whether the pathogenic treatments (corticosteroids, immunosuppressive agents, intravenous immunoglobulins, plasmapheresis) are effective for SLE associated PN.
 
  We searched MEDLINE for all the studieN, only retrospective case reports or case series which not only did they show contradictory results, but they also represent the lowest level of evidence. There is a strong need for new analytical studies dedicated to SLE associated PN.
  registered with PROSPERO (number CRD42019121748).
 There are no interventional studies dedicated to the SLE associated PN, only retrospective case reports or case series which not only did they show contradictory results, but they also represent the lowest level of evidence. There is a strong need for new analytical studies dedicated to SLE associated PN.Protocol registered with PROSPERO (number CRD42019121748).
  Dendritic cells (DCs) play an essential role in the induction and regulation of immune responses, including the activation of effector T lymphocytes for the eradication of cancers. However, the tumor microenvironment (TME) often leads to DCs dysfunction due to their immature state. MicroRNA-155 (miR-155) has emerged as a typical multifunctional gene regulator associated with immune system development and immune cell activation and differentiation.
 
  In this study, a three-dimensional TME model that closely mimics the microenvironment of breast cancer was prepared. MiR-155 overexpression and control vectors were constructed using lentivirus. The relative expression of miR-155 was determined by qRT-PCR. Cell viability, antigen uptake and cell surface marker expression were analyzed by live-dead staining and flow cytometry. The migration ability of bone marrow-derived DCs (BMDCs) was qualified by transwell assay. A mixed lymphocyte culture assay was used to assess T cell-specific proliferation. Cytokine levels were determined by ELISA.
 
  We found that the expression of miR-155 in DCs was inhibited by the TME. Furthermore, upregulation of miR-155 enhanced the migration ability, uptake of antigen and elevated the expression of the mature DCs markers CD80 and MHCII. More importantly, overexpression of miR-155 in DCs significantly induced T cell proliferation and IFN-γ and IL-2 secretion.
 
  MiR-155 is a potential molecular regulator that may improve the efficacy of DCs-based tumor immunotherapy.
 MiR-155 is a potential molecular regulator that may improve the efficacy of DCs-based tumor immunotherapy.