https://www.selleckchem.com/products/umi-77.html 982; 95% CI 0.779,3.185; large effect size D =.82). Significant main effects of time were found for the neuromuscular capacity of scapulothoracic muscles and for cervical mobility. No significant effects were found for balance, cervical muscle strength and endurance of cervical flexors. CONCLUSION Pain neuroscience education combined with cognition-targeted motor control training is not more effective than biomedically-focused education and exercise therapy for improving cervical motor output in people with chronic neck pain. Our findings question the relative importance of factors such as pain, disability and maladaptive pain cognitions on cervical motor output and the need to address it in treatment. This article is protected by copyright. All rights reserved.BACKGROUND Head and neck cancer (HNC) survivors experience head and neck lymphedema (HNL), which requires treatment to prevent morbidity. We explore the self-reported outcomes and satisfaction of patients with HNC receiving treatment for HNL with an advanced pneumatic compression device (APCD). METHODS HNC survivors (n = 205) prescribed with an at-home Flexitouch head and neck APCD completed pretreatment and posttreatment self-reported assessments addressing efficacy, function, and symptoms. Participant average age was 60 years with 74% male. Pre-post responses for ≥25 days of use were assessed via the non-parametric Wilcoxon Signed Rank test. RESULTS Analysis revealed statistically significant improvement in all symptoms and all function items (P  less then  0.00001). Compliance with prescribed therapy (at least 30 minutes daily) was high with 71% of participants reporting daily use and 87% reporting overall satisfaction. CONCLUSIONS The reported improvements in function and symptoms, and high compliance rate, provide a rationale for a subsequent randomized controlled trial. © 2020 The Authors. Head & Neck published by Wiley Periodicals, Inc.The alkylation of