Participants with sufficient levels of serum 25(OH)D at baseline, consuming the intervention diet increased FEV1/FVC by 4.89 units (β = 4.89; 95%CI 1.19-8.61; p = 0.013) and FEF25-75% by 12.83 units (β = 12.83; 95%CI 4.27-21.40; p = 0.006) compared to controls. No significant differences in pulmonary function or FeNO were observed for those with insufficient levels of 25(OH) D in the intervention or control groups. In conclusion, sufficient serum vitamin D levels enhanced ventilatory function in response to a dietary intervention in asthmatic children.In aquatic ecosystems, the temperature of the water is an important ecological factor that modulates aquatic organisms' metabolism, growth, development, and reproduction. In this study, the morphological, transcriptomic, and metabolomic analyses of response of Marsupeneus japonicus to acute cold stress was investigated. The results revealed that low temperature caused profound morphological damage to the hepatopancreas. Transcriptomic responses suggested that energy and primary metabolism, cytoskeleton structure, and apoptosis signaling were altered. The metabolic responses to cold stress included changes of multiple amino acids and unsaturated fatty acids. Combined transcriptomic and metabolomic data indicated that energy metabolism pathways were downregulated in the hepatopancreas under cold stress. However, M. japonicus increased ATP and unsaturated fatty acids production to ameliorate. Moreover, cold stress caused significant attenuation of macrophage apoptosis. This study provides key information to increase our understanding of low-temperature tolerance in shrimp.The aim of the study was to investigate the protective effects of selenium yeast (SeY) against necroptosis triggered by Cd via inhibition of oxidative stress and MAPK pathway in the liver of chicken.  https://www.selleckchem.com/products/camostat-mesilate-foy-305.html  Two hundred 120-day-old layers were randomly divided into four groups and raised for 120 days. The histopathological examination showed that necrosis characteristics were observed in Cd-exposed chicken livers. The exposure of Cd significantly reduced the activities of SOD, GSH-Px and CAT while improving MDA level in both serum and liver of chickens (P less then 0.05), and induced oxidative stress. The MLKL, Rip1, RIP3, ERK, JNK and P38 mRNA expression of Cd group were significantly higher than other three groups (P ＜ 0.01), and those in the Se + Cd group were significantly higher than control group and Se group (P ＜ 0.01). However, the mRNA expression level of caspase8 of Cd was significantly lower than other three groups (P ＜ 0.01), and that in the Se + Cd group was significantly higher than control group and Se group (P ＜ 0.01), so the supplement of SeY could improve these situations. Similar results were also detected at the protein level. The results of the present study indicated that Cd could induce oxidative stress, activate MAPK pathway and evoke necroptosis damage in chicken livers, whereas SeY had protective effects in preventing this kind of Cd-induced injury by inhibition of oxidative stress and down-regulation MAPK pathway.The problem of heavy metal pollution in sediments attracts increasing attention with the process of industrialization. In this study, a novel sediments amendment granular activated carbon (GAC)-supported titanium dioxide nanoparticles (GATN) was synthesized to amend copper (Cu)-contaminated sediments. The effect of the amendments on the potential mobility and bioavailability of Cu was evaluated by the concentration of Cu in the overlying water and the chemical speciations of Cu in sediments. After 35 days of incubation, GATN and GAC were separated from the GATN-amended sediments and the GAC-amended sediments. The European Community Bureau of Reference (BCR) sequence extraction procedure was performed on the separated sediments. Compared with the control group, the addition of 20% GATN amended sediments for 35 days, the Cu concentration in the overlying water decreased by 90.75%. Compared with original sediments, the exchangeable fraction and reducible fraction of Cu decreased from 42.30% to 17.36%-3.63% and 6.57%, respectively, and the oxidizable fraction and residual fraction of Cu increased from 13.57% to 26.77%-33.21% and 56.58%, respectively. The potential mobility and bioavailability of Cu were significantly reduced. According to the BCR sequence extraction results of the remaining sediments after the separation of the GATN, the Cu adsorbed on the GATN surface is mainly an oxidizable fraction, which is generated by the complexation reaction of hydroxyl (-OH) and Cu2+. Meanwhile, the present of GATN also can enhance the remediation capacity of sediments, which plays an important role during the amendment process. The pH was measured after GATN-amended sediments adding. Results showed that GATN improved their remediation capacity of sediments by optimizing the pH in sediments. The enzyme activity-experiment indicated that GATN effectively reduces the biological toxicity of Cu in Cu-contaminated sediments. Results verified that GATN, as a sediments amendment, has good application potential.In this study, a new electrochemical method was used to simultaneously efficient removal of Mn2+ and NH4+-N in wastewater with Cu plate as cathode. The effects of various reaction parameters on the concentrations of Mn2+, NH4+-N and by-products (NO3--N and NO2--N, free chlorine and residual chlorine), as well as the removal mechanism were investigated. The results showed that the removal efficiencies of Mn2+ and NH4+-N were 99.1% and 92.9%, and the concentrations of NO3--N, NO2--N, free chlorine and residue chlorine were 0.73 mg/L, 0.15 mg/L, 0.13 mg/L and 0.63 mg/L reacting for 3 h at room temperature, respectively, when the current density was 10 mA/cm2, the mass ratio of ClO- and Cl- was 11, the initial pH was 9. The concentrations of Mn2+, NH4+-N and by-products in wastewater met the integrated wastewater discharge standard (GB8978-1996). In addition, spherical manganese oxide was deposited on the anode plate, and spherical manganese oxide collapsed over electrolysis time. Manganese was mainly removed in the form of MnO, Mn(OH)2 and MnO2.