https://www.selleckchem.com/products/tasin-30.html 05). There was no significant difference between the groups in terms of intraoperative sevoflurane and remifentanil consumptions ( > .05). Rescue opioid analgesic requirements were significantly lower in group K than group C (0/24 vs 6/24, respectively;  = .022). Side effects were similar between the groups ( > .05). We recommend the administration of low-dose ketamine infusion during septorhinoplasty surgery because it reduces the requirement for rescue opioid analgesia and postoperative pain scores. We recommend the administration of low-dose ketamine infusion during septorhinoplasty surgery because it reduces the requirement for rescue opioid analgesia and postoperative pain scores.Purpose To characterize a genetic mutation causing Stickler syndrome in a previously undiagnosed family. Methods Five generations of a single family suspected of having Stickler syndrome were evaluated clinically and genetically. Results The demographic and clinical data yielded specific clinical phenotypes of Stickler syndrome in 13 family members; 7 had more than one clinical feature. Four family members underwent genetic analysis the proband (index patient) and his mother, maternal grandfather, and healthy father. No relevant mutation was detected in the proband on whole exome analysis, but subsequent extension of the analysis to intronic areas yielded a deep intronic mutation, NM_001844.5c.1527 + 135 G > A. Sanger sequencing was used to validate the results in the family members. Conclusions Stickler syndrome has several subtypes with variable clinical features. Therefore, predicting the genetic locus of the disease based on clinical characteristics is challenging. We present a rarely described intronic mutation in COL2A1. Genetic testing may aid in the early diagnosis of Stickler syndrome, which is important for genetic counselling, proper clinical management, and improved prognosis. Hepatocellular carcinoma (HCC) is a major healt