Cerebral vasculopathy is the most severe complication affecting children with sickle cell anemia. Significant progress has been made in the management of sickle cell anemia cerebral vasculopathy, including early transcranial Doppler screening, chronic transfusion, andhydroxyurea. Nevertheless, for patients with a potential matched-sibling donor (MSD), stem cell transplantation (SCT) is now the treatment offering the best cerebral vasculopathy outcome. In the absence of MSD,alternative SCT should be recommended only in those with worsening cerebral vasculopathy despite standard treatments, and should be limited to related haplo-identical SCT undertaken in controlled studies. Antithymocyte globulin (ATG) is a widely accepted part of the conditioning regimen applied in the setting of hematopoietic stem cell transplantation (HSCT) to prevent graft rejection and graft-versus-host disease. Although weight-based dosing of ATG has been introduced to optimize ATG dosing, substantial variance in clearance of active ATG, the actual lymphocyte binding component, remains a challenge. Therefore, further research regarding ATG pharmacokinetics and pharmacodynamics in different HSCT settings and in patients with different types of underlying diseases is required. A severe outbreak of coronavirus disease 2019 (COVID-19) emerged in China in December 2019, and spread so rapidly that more than 200,000 cases have so far been reported worldwide; on January 30, 2020, the WHO declared it the sixth public health emergency of international concern. The two previously reported coronavirus epidemics (severe acute respiratory syndrome [SARS] and Middle East respiratory syndrome [MERS]) share similar pathogenetic, epidemiological and clinical features as COVID-19. As little is currently known about SARS-CoV-2, it is likely that lessons learned from these major epidemics can be applied to the new pandemic, including the use of novel immunosuppressive drugs.The article takes as its starting point the relationship of academic economists and the wider society. First, various bodies of literature that deal empirically with this matter are discussed epistemologically, they range from a bold structuralism via a form of symbolic interactionism to a form of radical constructivism. A Bourdieusian approach is recommended to complement these perspectives with a comprehensive perspective that is sensible to the cultural differences between social groups. Starting from the established notions of field, capital and habitus, the article then attempts to go the initial steps towards formulating a theory of the specificity of academic economics, taking Germany as its example. For that it uses and compares in-depth interviews of recognized and non-recognized German economics students. It shows the thorough interweaving of specific normative and positive dispositions into a conviction of objectivity and disinterestedness. This exploratory empirical induction furthers follow-up questions, the empirical answering of which may help to gain a more complete understanding of the actions and thoughts of economists in their specific contexts.In this paper we comparatively explore three claims concerning the disciplinary character of economics by means of citation analysis. The three claims under study are (1) economics exhibits strong forms of institutional stratification and, as a byproduct, a rather pronounced internal hierarchy; (2) economists strongly conform to institutional incentives; and (3) modern mainstream economics is a largely self-referential intellectual project mostly inaccessible to disciplinary or paradigmatic outsiders. The validity of these claims is assessed by means of an interdisciplinary comparison of citation patterns aiming to identify peculiar characteristics of economic discourse. In doing so, we emphasize that citation data can always be interpreted in different ways, thereby focusing on the contrast between a "cognitive" and an "evaluative" approach towards citation data.Following an international trend, Italy has reformed its university system, especially concerning methods and tools for research evaluation, which are increasingly focused on a number of bibliometric indexes. To study the effects of these changes, we analyze the changing profiles of economists who have won competitions for full professorship in the last few decades in the country. We concentrate on individual characteristics and on scientific production. We show that the identification of a univocal and standardized concept of "research quality" within the new research assessments has progressively imposed a strategy of "homologation," especially for women. We find that women economists are at a higher risk of discrimination than their male colleagues and thus they are more likely to conform their research activities to the standardized profile imposed by the gender-blind application of simplistic bibliometric methods.Recurring economic crises, like the one of 2007-2008, led to criticism of economic research and a demand to develop new strategies to avoid them. Standard economic theories use conventional approaches to deal with economic challenges, heterodox theories try to develop alternatives with which to face them. It remains unclear whether the 2007-2008 crisis led to a change in economic research as well as to a consideration of alternative approaches. We used co-word analysis to map the structure of economic research in Germany between 2005 and 2014. Core topics within economic research, such as "market" or "production" hardly shift and can be linked to standard economic theories. Peripheral topics such as "inequality" or "unemployment" show greater dynamics. However, only a few of these topics can be linked to heterodox approaches. Certain changes have occurred in reaction to the 2007-2008 crisis. However, the unchanged importance of standard economic topics raises the question whether these changes are sufficient to face coming economic challenges.This paper argues that the economics discipline is highly concentrated, which may inhibit scientific innovation and change in the future. The argument is based on an empirical investigation of six dimensions of concentration in economics between 1956 and 2016 using a large-scale data set. The results show that North America accounts for nearly half of all articles and three quarters of all citations. Twenty institutions reap a share of 42 percent of citations, five journals a share of 28.5 percent, and 100 authors a share of 15.5 percent.  https://www.selleckchem.com/products/combretastatin-a4.html  A total of 2.8 percent of citations may be attributed to heterodox schools of thought. Also top articles are concentrated along these dimensions. Overall, concentration has strongly increased over the last six decades.