Injury to the renal artery following blunt trauma is detected increasingly due to widespread and early use of multidetector computed tomography (CT), but optimal treatment remains controversial as no guidelines are available. This review illustrates the spectrum of imaging findings of traumatic renal artery dissection based on our experience, with the aim of understanding the physiopathology of ischaemic damage to the kidney, and the process of choosing the best therapeutic strategy (conservative, endovascular, surgical). Five main patterns of traumatic renal artery dissection are described avulsion of renal hilum; dissection of the segmental renal branches; preocclusive main renal artery dissection; renal artery stenosis without flow limitation; thrombogenic renal artery intimal tear. In the polytrauma patient, management depends on various factors (haemodynamic status, associated lesions, time of diagnosis) rather than on the degree of renal artery stenosis. Non-operative management (NOM) is the preferred option in case of non-flow-limiting dissection of the renal artery and angio-embolisation is an important adjunct to NOM in cases of active bleeding. Embolisation of the renal artery stump may be the best option in cases of occlusive dissection, as catheter manipulation carries a high risk of vessel rupture. The therapeutic window for kidney revascularisation in cases of flow-limiting dissection of main renal artery may be variable. Endovascular stenting >4 h after trauma should be performed only if residual flow with preserved parenchymal perfusion is detected at angiography. Antiplatelet therapy administration is recommended in cases of stenting, but conditioned by the bleeding risk of the patient.
  To evaluate the ultra-lose dose imaging protocol (ULDP), compared to the standard low-dose imaging protocol (LDP), which are used for haemodialysis access, in terms of radiation exposure and image quality.
 
  This was a single-centre, institutional review board-approved, prospective, double-blinded randomised controlled study to compare radiation exposure and image quality of the ULDP and LDP. Ten proceduralists, two radiographers, and 11 nurses were enrolled. Radiation exposure during 80 procedures (40 angioplasties and 40 thrombolysis) was recorded (direct radiation to patients from protocol report and scattered radiation to participants from the RaySafe i2 real-time dosimetry system). Baseline characteristics of procedure were recorded. Image quality was assessed subjectively using questionnaires based on the five-point Likert scale after each procedure.
 
  Compared with LDP, the use of ULDP was associated with a significantly lower rate of radiation exposure to proceduralists, patients, and scrub nurses (0.506±0.430 versus 0.847±0.965 μSv/s, p=0.044; 0.571±1.284 versus 1.284±1.007 mGy/s, p<0.001; and 0.052±0.071 versus 0.141±0.185 μSv/s, p=0.005, respectively). No significant difference in image quality or duration of procedure was observed (all p values >0.05).
 
  Compared with LDP, the use of ULDP was associated with a significantly lower rate of radiation exposure to proceduralists, patients, and scrub nurses without compromising the image quality or duration of procedure.
 Compared with LDP, the use of ULDP was associated with a significantly lower rate of radiation exposure to proceduralists, patients, and scrub nurses without compromising the image quality or duration of procedure.A water-soluble probe with p-hydroxybenzyl quaternary ammonium linker, FR-2a, for selective imaging in senescent cells is reported. Probe FR-2a integrated water-soluble fluorophore (HT-4a) and β-galactosidase (β-gal) trigger into one entity by a p-hydroxybenzyl quaternary ammonium linker. HT-4a is a styryl-based push-pull benzothiazole fluorophore with attractive properties, including excellent water-solubility, intense fluorescence emission and a large Stokes shift (161 nm), characterized by an intramolecular charge transfer (ICT) excited state. The formation of quaternary ammonium deactivated the ICT state, resulting in fluorescence quenching of FR-2a. In the presence of β-gal, the glycosidic bond was hydrolyzed and fluorophore HT-4a was released through self-immolative process, resulting in effective fluorescence recovery. FR-2a shows high affinity to β-gal (Km = 1.33 μM), exhibiting good sensitivity, selectivity and stability for imaging in senescent cells.Sulfonamides antibiotic residues are commonly found in environmental samples, which is highly concerning for public safety and environmental protection. The detection of sulfonamides antibiotics (SAs) is quite important but challenging. In this work, functionalized Zr metal-organic frameworks (Zr-MOFs) and imidazole-based ionic liquids (ILs) were selected and designed according to the structures and properties of SAs. By supporting functionalized ILs into the water-stable Zr-MOFs, the novel ILs@Zr-MOFs nanocomposites were synthesized for the pretreatment of SAs. [H2Nmim][NTf2]@UiO-66-Br showed good selectivity for SAs with maximum adsorption capacity of 352.1 mg g-1 for sulfadiazine. The satisfied performance attributed to not only the large BET surface areas, but also the multiple interactions between the adsorbent and SAs, including electrostatic interaction, hydrogen bonding interaction and π-π interaction. The as-prepared nanocomposites were applied to the dispersive solid phase extraction of SAs in environmental water samples. Combined with high performance liquid chromatography-diode array detector (HPLC-DAD), the effective extraction and sensitive analysis of SAs was achieved by [H2Nmim][NTf2]@UiO-66-Br with enrichment factors higher than 270 and extraction recoveries between 90.5% and 101.9% in short extraction time (10 min). The detection limits were lower than 0.03 μg L-1.In pharmaceutical development, forced degradation studies are mandatory before the commercialization of any drug product. They aim at identifying the possible degradation routes and the potential products that may be formed during drug product shelf life. The most widely used techniques for monitoring this in the pharmaceutical industry are hyphenated techniques such as Liquid Chromatography coupled to ultraviolet diode array detector (LC-DAD). There are however some drawbacks, such as long analysis times required for the elution of all compounds and coelution, which is not easily detected since degradation products usually have spectra very similar to that of the drug. Chemometrics methods applied to LC-DAD data are capable of solving this issue, but the approaches described in the literature first require peak alignment to solve the rank deficiency problem, which is a delicate preprocessing method for high order data.  https://www.selleckchem.com/peptide/octreotide-acetate.html  The present work describes another approach where extra information - the kinetic degradation profiles - is included for the modelling, generating a third-order data set for each sample, resulting in a four-way array (sample x retention times x spectra x degradation profile).