We further demonstrate the incorporation of various transition metal atoms, such as iron (Fe), rhenium (Re), and vanadium (V), into the lattice of TMD monolayers to form Fe-doped WS2, Re-doped MoS2, and more complex material systems such as V-doped in-plane WxMo1-xS2-MoxW1-xS2 heterostructures, among others. We envisage that our developed approach is universal and could be extended to incorporate a variety of other elements into 2D TMDs and create in-plane heterointerfaces in a single step, which may enable applications such as electronics and spintronics at the 2D limit.When antibiotics are administered, orally or intravenously, they pass through different organs and layers of tissue on their way to the site of infection; this can cause dilution and/or intoxication. To overcome these problems, drug delivery vehicles have been used to encapsulate and deliver antibiotics, improving their therapeutic index while minimizing their adverse effects. Liposomes are self-assembled lipid vesicles made from at least one bilayer of phospholipids with an inner aqueous compartment. Liposomes are attractive vehicles to deliver antibiotics because they can encapsulate both hydrophobic and hydrophilic antibiotics, they have low toxicity, and they can change the biodistribution of the drug. Furthermore, liposomes have been approved by regulatory agencies. However, most developmental and mechanistic research in the field has been focused on encapsulation and delivery of anticancer drugs, a class of molecules that differ significantly in chemistry from antibiotics. In this critical Review, we discuss the state of knowledge regarding the design of liposomes for encapsulation and delivery of antibiotics and offer insight into the challenges and promises of using liposomes for antibiotic delivery.Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that has been associated with the deposition of aggregates of superoxide dismutase 1 (SOD1). Effective therapeutics against SOD1 fibrillation is still an area of active research. Herein, we demonstrate the potential of two naturally occurring flavonoids (quercetin and baicalein) to inhibit fibrillation of wild-type SOD1 with the aid of a series of biophysical techniques. Our seeding experiments reveal that both of these flavonoids significantly affect the fibril elongation. Interestingly, our ThT binding assay, TEM, and SDS-PAGE experiments suggest that these flavonoids also disintegrate the fibrils into shorter fragments but do not completely depolymerize them into monomers. Binding parameters obtained from the analysis of UV-vis spectra suggest that these flavonoids bind moderately to native SOD1 dimer and have different binding sites. Docking of these flavonoids with a non-native monomer, non-native trimer, and oligomer derived from the 11-residue segment of SOD1 indicates that both quercetin and baicalein can bind to these species and thus can arrest the elongation of fibrils by blocking the fibrillar core regions on the intermediate species formed during aggregation of SOD1. MTT assay data revealed that both the flavonoids reduced the cytotoxicity of SOD1 fibrils. Experimental data also show the antiamyloidogenic potential of both flavonoids against A4V SOD1 mutant fibrillation. Thus, our findings may provide a direction for designing effective therapeutic agents against ALS which can act as promising antiamyloidogenic and fibril destabilizing agents.Two-dimensional (2D) materials have been incorporated into calcium silicate hydrate (C-S-H) gel to enhance its mechanical performance for decades, while the modified C-S-H gel exhibits poor toughness, tensile strength, and ductility. In this work, we report a new design strategy and synthesis route to strengthen C-S-H interface by intercalating a silicene sheet of one atom thickness. The hybrid C-S-H/Silicene gel shows superb mechanical properties, with a remarkable enhancement in strength and other functional properties. By using density functional theory (DFT) and molecular dynamics (MD) simulations, we have demonstrated that Si-O bonds between silicene and C-S-H are stable and covalent, and the interaction energy of this bilayer gel nearly doubles by forming a 3D covalent network with a strong bridging effect. Owing to its better crystallinity enrichment and its induced dislocation dissipation mechanism, the hybrid C-S-H/Silicene gel possesses a higher tensile ductility (∼118% average enhancement and ∼228% in the c direction) and a much smaller elastic stiffness (59.04 GPa for average Young's modulus). This work offers an ingenuous route in turning brittle C-S-H gel into a soft gel, which provides opportunities for fabricating ultrahigh performance cementitious materials.Flexible electromagnetic interference (EMI) shielding materials with excellent thermal conductivities and Joule heating performances are of urgent demand in the communication industry, artificial intelligence, and wearable electronics. In this work, highly conductive silver nanowires (AgNWs) were prepared using the polyol method. Cellulose sheets were then prepared by dissolving natural cotton in a green and efficient NaOH/urea aqueous solution. Finally, multifunctional flexible EMI shielding AgNWs/cellulose films were fabricated based on vacuum-assisted filtration and hot-pressing. AgNWs are evenly embedded in the inner cellulose matrix and overlap with each other to form a 3D network. AgNWs/cellulose films, with a thickness of 44.5 μm, obtain the superior EMI shielding effectiveness of 101 dB, which is the highest value ever reported for shielding materials with the same thickness.  https://www.selleckchem.com/products/larotrectinib.html  In addition, AgNWs/cellulose films present excellent tensile strength (60.7 MPa) and tensile modulus (3.35 GPa), ultrahigh electrical conductivity (σ, 5571 S/cm), and excellent in-plane thermal conductivity coefficient (λ∥, 10.55 W/mK), which can effectively dissipate the heat accumulation. Interestingly, AgNWs/cellulose films also show outstanding Joule heating performances, good stability, and sensitive temperature response at driving voltages, absolutely safe for the human body. Therefore, our fabricated multifunctional flexible AgNWs/cellulose films have broad prospects in the fields of EMI shielding and protection of outdoor large-scale power transformers and wearable electronics.