https://www.selleckchem.com/products/bay-218.html Among antibodies, IgA is unique because it has evolved to be secreted onto mucosal surfaces. The structure of IgA and the associated secretory component allow IgA to survive the highly proteolytic environment of mucosal surfaces but also substantially limit IgA's ability to activate effector functions on immune cells. Despite these characteristics, IgA is critical for both preventing enteric infections and shaping the local microbiome. IgA's function is determined by a distinct antigen-binding repertoire, composed of antibodies with a variety of specificities, from permissive polyspecificity to cross-reactivity to exquisite specificity to a single epitope, which act together to regulate intestinal bacteria. Development of the unique function and specificities of IgA is shaped by local cues provided by the gut-associated lymphoid tissue, driven by the constantly changing environment of the intestine and microbiota.This review aimed to give comprehensive information about the interactions between free and bound antioxidants naturally found in different food matrices. In this context, firstly, the free and bound antioxidant terms are defined; their place in the daily diet, the path they follow in the body and their characteristics are explained. Factors affecting the interactions have been revealed as a result of the compilation of studies conducted until today, related to bound and free antioxidant interactions. Accordingly, it was observed that many factors such as reaction environment, concentration, pH, chemical structure, source and antioxidant/prooxidant nature of the compounds were effective on interactions. It has been emphasized that the interactions between free and bound antioxidants have a dynamic balance that can easily change under the influence of various factors, which in turn needs the interactions to be handled specifically for each case. The choline derivative (CD) and polyethylene-glycol (PEG) dually