https://www.selleckchem.com/products/cnqx.html 3 vs 0.7 points, p=0.003) compared to N-NfL group (n=76). In linear regression analyses plasma NfL emerged as the best predictor of 2-year motor progression compared to age, sex, disease duration, baseline motor/non-motor variables. increased plasma NfL concentration is associated with malignant PD phenotype and faster motor progression. These findings support the role of NfL assessment as a useful measure for stratifying patients with different baseline slopes of decline in future clinical trials of putative disease-modifying treatments. increased plasma NfL concentration is associated with malignant PD phenotype and faster motor progression. These findings support the role of NfL assessment as a useful measure for stratifying patients with different baseline slopes of decline in future clinical trials of putative disease-modifying treatments.Due to the increasing concerns of global warming and short instrumental records of sea surface temperature (SST), coral-based proxies, such as δ18O, Sr/Ca, U/Ca, and Li/Mg have been developed and applied to reconstruct SST in paleoclimate studies. However, these proxies are not universally applicable in different environments, because they are affected by coral physiology and various environmental factors. In this study, seven long-lived Porites corals were collected from the southern sector of the Great Barrier Reef (GBR) off the coast of Gladstone and the central sector of the GBR within the Whitsunday Islands in 2017 and 2018. Coral sites were selected to cover a wide latitudinal range with different annual temperature ranges. Century-long geochemical records (Li/Ca, B/Ca, Mg/Ca, Sr/Ca, and U/Ca) were generated using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) at weekly resolution. This study has tested the robustness of two traditional temperature proxies (Sr/Ca and U/Ca), a recently developed temperature proxy (Li/Mg), and an additional potential t