Predominance of SARS- CoV2 infection was found in male HCWs (57%) than female HCWs (43%). HCWs younger than 45 years (68%) were more infected.52 (69%) HCWs presented with symptoms like fever, sore throat, bodyache, loss of sensation of smell, coughs etc. 23(31%) were asymptomatic with history of direct contact with Covid-19 positive cases. Heath care workers are at higher risk of being exposed to SARS-CoV2 and could potentially has a role in transmission in and out of the hospital. https://www.selleckchem.com/products/s-2-hydroxysuccinic-acid.html Hence, routine screening of both symptomatic as well as asymptomatic hospital staff is essential for early diagnosis to prevent transmission of COVID 19 infection. Heath care workers are at higher risk of being exposed to SARS-CoV2 and could potentially has a role in transmission in and out of the hospital. Hence, routine screening of both symptomatic as well as asymptomatic hospital staff is essential for early diagnosis to prevent transmission of COVID 19 infection. Clinical and laboratory features of COVID-19 may have regional variations. This study aimed to discern their association with severity of illness and mortality in tertiary setup of Delhi, India. Retrospective data of hospitalised COVID-19 patients over 3 months (end March to June 2020) were evaluated for symptom profile, blood investigations and chest radiograph data and classified according to COVID-19 severity and as survivors and non-survivors. Average age (n=182) was 46.1 years, male to female ratio 1.41. Fever (51.1%), cough (49.4%) and breathlessness (48.3%) were the commonest symptoms, and frequency of all the three increased with severity of COVID-19. Fever duration, leucocytosis, neutrophilia, elevated blood urea, transaminitis and higher Brixia score on chest X-ray were also more in severe COVID-19 compared to mild and moderate categories. Higher age, more comorbidities, fever, breathlessness and chest pain; longer duration of fever, leucocytosis, neutrophilia, lymphopenia, high neutrophil to lymphocyte ratio, elevated serum urea, creatinine, transaminases and hyperglycemia, and higher radiographic Brixia score were observed in non-survivors compared to survivors. Greater prevalence of symptoms (alone and in combination) and derangements in blood biochemistry are seen in severe COVID-19 compared to mild or moderate cases, and also in non-survivors compared to survivors. Greater prevalence of symptoms (alone and in combination) and derangements in blood biochemistry are seen in severe COVID-19 compared to mild or moderate cases, and also in non-survivors compared to survivors.Though Convalescent plasma therapy (CPT) is being used for management of COVID-19, the evidence is still equivocal. So, we carried out this study to evaluate the currently available data to provide evidence about CPT in COVD-19 patients. RCTs and observational studies with sample size with more than 5 were included in the analysis. Out of 196 studies, 12 studies were selected for systematic review and meta-analysis was carried out for 6 studies having a control arm. For dichotomous values, risk ratio (RR) and 95% confidence interval was expressed. All-cause mortality, clinical improvement by day 7 and viral detection by day 7 were the defined outcome measures before starting of data extraction. For 6 studies (2 RCTs and 4 observational studies) with 474 patients, the overall pooled RR for all-cause mortality was 0.61 (95%CI 0.37 to 0.99. P= 0.04). Only RCTs and only observational studies for all-cause mortality showed pooled RR of 0.60 (95% CI 0.33 to 1.10, P=0.10) and 0.48 (95% CI 0.17 to 1.36, P= 0.17) respectively. There was risk of bias in the studies due to randomization process and confounding. Sensitivity analysis was carried out only for observational studies. The overall pooled RR for clinical improvement by day 7 and viral detection by day 7 were 1.12 (95%CI 0.96 to 1.31, P=0.16) and 0.19 (95%CI 0.09 to 0.60, P < 0.0001). Though the review suggests modest utility of CPT in reducing all-cause mortality, improving clinical outcome, and early viral clearance, it should be interpreted cautiously. Though the review suggests modest utility of CPT in reducing all-cause mortality, improving clinical outcome, and early viral clearance, it should be interpreted cautiously. Incidence of viral pneumonia has been reported in several patients diagnosed with COVID-19. The infection has also been linked to the development of inflammatory syndromes and related clinical manifestations. The present study discusses four cases of COVID infection showing varying clinical features. The post-COVID inflammation syndrome was associated with non-specific inflammation and post viral arthritis in three cases. One other subject had vasculitis leading to central retinal artery occlusion. As the number of cases of COVID-19 cases has been increasing globally, it is advisable that physicians consider the possibility of post-COVID manifestations while examining patients with non-specific inflammation. A short course of NSAIDs and hydroxychloroquine regimen has been found to be beneficial for alleviating symptoms, and in rare cases with organ threatening inflammation, steroids may be required. As the number of cases of COVID-19 cases has been increasing globally, it is advisable that physicians consider the possibility of post-COVID manifestations while examining patients with non-specific inflammation. A short course of NSAIDs and hydroxychloroquine regimen has been found to be beneficial for alleviating symptoms, and in rare cases with organ threatening inflammation, steroids may be required. Nearly three months after its first recorded case, the progression of the coronavirus disease (COVID-19) pandemic has been slow in India so far, with relatively low number of cases and deaths. The behavior of the general public will probably have the most important bearing on the course of the disease over the next few months in India. We aim to study the awareness, attitudes and perceptions of COVID-19 among the adult Indian population. A cross-sectional online survey was conducted using the 'Google Survey Forms' between 29th March and 14th April 2020 and distributed through email and various social media groups. There were 1502 respondents, majority were male (56.7%), between 30-49 years (47.7%). 90% of the respondents had either an undergraduate or postgraduate degree, with a third of them being in the healthcare sector (34.6%). Most of the respondents were aware of the common symptoms of COVID-19, but worryingly only a third (31%) were aware of the risk of spread from infected asymptomatic individuals, which is a major concern in India.