Brazil is the country with the highest social inequality in South America. This socioeconomic disparity reflects not only on the families' income but also on their spatial localization in the city, as well as on the urban design. These urban environments can alter the urban microclimate, and consequently, interfere in dwellers' thermal comfort. This research investigated the relationship between socio-spatial inequalities and thermal comfort in two different Local Climate Zones (LCZ) using a combination of measurement and modeling. Air temperature (Tair) was obtained by on-site measurements in compact high-rise (LCZ1) and compact low-rise buildings (LCZ3) and Mean radiant temperature (Tmrt) was simulated using SOlar and LongWave Environmental Irradiance Geometry (SOLWEIG). The results indicated that in LCZ1 seafront-localized buildings, in which residents have a higher income, the temperature remains in a range classified as comfortable, mainly due to shading and sea breeze. On the other hand, LCZ3, located in the periphery of the city, in which the low-income population is concentrated and is marked by a precariousness urban environment, presented a higher air temperature and Tmrt values, exposing the dwellers to heat stress throughout the year, especially during the summer season. These observations suggested that public and private actions tend to promote better urban designs in areas with a higher concentration of income. Public reforms aimed at improving the urban environment and promoting thermal comfort should be a priority for the warmest LCZ, where the poorest residents live. Public agents should rethink the distribution of environmental resources to promote equitable urban spaces.Current therapies for patients with critical limb ischemia have not reduced amputation risk owing to poor cell engraftment.  https://www.selleckchem.com/products/dinaciclib-sch727965.html  The recombinant peptide Cellnest increases the engraftment rate of administered cells by forming a complex with the cells (CellSaic). We hypothesized that CellSaic containing adipose-derived stromal cells (ADSCs) could improve lower limb blood flow better than ADSCs alone, resulting in better transplanted cell engraftment. ADSCs were extracted from 8-week-old C57BL/6N mice. Thirty-two critical limb ischemia model mice were established by ligating femoral arteries. They were divided into CellSaic (n = 11), ADSC (n = 10), saline (n = 9), and Cellnest (n = 9) groups. Blood flow rate (affected side blood flow / healthy side blood flow × 100%) was evaluated using a laser Doppler blood flow meter every week. Mice were euthanized on day 28 for histological evaluation. Compared with the ADSC group (54.5 ± 17.2%), treated side blood flow rate of the CellSaic group (78.0 ± 24.9%) showed significant improvement on day 28 after administration (p  less then  0.05). CD31 staining showed significantly higher number of capillary vessels in the CellSaic group (53.0 ± 8.9 cells/mm3) than in the ADSC group (43.0 ± 6.8 cells/mm3) (p  less then  0.05). Fluorescent staining showed significantly higher number of arterioles containing both CD31 and αSMA double-positive cells in the CellSaic group than in the ADSC group (p  less then  0.05). CellSaic containing ADSCs exhibited superiority to ADSC transplantation alone in promoting functional angiogenesis, suggesting its potential in improving clinical outcomes of angiogenic therapy for ischemic limbs.By extending a mechanistic model for the tick-borne pathogen systemic transmission with the consideration of seasonal climate impacts, host movement as well as the co-feeding transmission route, this paper proposes a novel modeling framework for describing the spatial dynamics of tick-borne diseases. The net reproduction number for tick growth and basic reproduction number for disease transmission are derived, which predict the global dynamics of tick population growth and disease transmission. Numerical simulations not only verify the analytical results, but also characterize the contribution of co-feeding transmission route on disease prevalence in a habitat and the effect of host movement on the spatial spreading of the pathogen.Astragaloside IV (AsIV), an active ingredient isolated from traditional Chinese medicine astragalus membranaceus, is beneficial to cardiovascular health. This study aimed to characterize the functional role of AsIV against adriamycin (ADR)-induced cardiomyopathy. Here, healthy rats were treated with ADR and/or AsIV for 35 days. We found that AsIV protected the rats against ADR-induced cardiomyopathy characterized by myocardial fibrosis and cardiac dysfunction. Meanwhile, ADR increased type I and III collagens, TGF-β, NOX2, and NOX4 expression and SMAD2/3 activity in the left ventricles of rats, while those effects were countered by AsIV through suppressing oxidative stress. Moreover, ADR was found to promote cardiac ferroptosis, whereas administration of AsIV attenuated the process via activating Nrf2 signaling pathway and the subsequent GPx4 expression increasing. These results suggest that AsIV might play a protective role against ADR-induced myocardial fibrosis, which may partly attribute to its anti-ferroptotic action by enhancing Nrf2 signaling.
  Sport-related concussion (SRC) is a significant public health problem. Understanding the behavioral and personal factors that influence risk and incidence of SRC is critically important for appropriate care and management. Sensation-seeking and impulsivity have been posited to be two such factors that may be significantly associated with SRC. We performed a focused review of recent evidence of the relationships between sensation-seeking and impulsivity in athletes with SRC.
 
  While the research is relatively limited, extant findings demonstrate a significant relationship between sensation-seeking and contact sport participation and risk of prior and future SRC. Impulsivity appears to be common among athletes competing in high contact sports and may contribute to neural and functional brain changes following SRC; however, causal relationships between impulsivity, contact sport participation, and SRC have not been demonstrated. Both sensation-seeking and impulsivity are significantly associated with SRC in collegiate athletes.